Awards & Honors
Award | Conferred By | Date |
---|---|---|
Distinguished Pharmaceutical Scientist Award | American Association of Pharmaceutical Scientists | 2021 |
B.B. Brodie Award | American Society of Pharmacology and Experimental Therapeutics | 2020 |
Volwiler Research Achievement Award | American Association of Colleges of Pharmacy | 2018 |
Scheele Award | Swedish Academy of Pharmaceutical Scientists | 2011 |
Therapeutic Frontiers Lecture Award | Therapeutic Frontiers Lecture Award | 2010 |
Rawls-Palmer Progress in Medicine Award | American Society for Clinical Pharmacology and Therapeutics | 2009 |
Outstanding Mentor Award | Postdoctoral Scholars Association, University of California, San Francisco | 2009 |
Invitation Fellowship Program for Research in Japan | Japan Society for the Promotion of Science | 2008 |
International Woman Scientist Award | Academy of Pharmaceutical Sciences and Technology, Japan | 2007 |
Research Achievement Award | Pharmaceutical Sciences World Congress | 2007 |
Distinguished Scientist Award in Drug Metabolism | American Association of Pharmaceutical Scientists | 2006 |
Elected Member | National Academy of Medicine | 2006 |
Paul Dawson Biotechnology Award | American Association of Colleges of Pharmacy | 2005 |
Distinguished Gerhard Levy Lectureship | State University of New York at Buffalo | 2002 |
Distinguished Bill Abram's Lectureship | U.S. Food and Drug Administration | 2002 |
Honored Celebrating Women Faculty | University of California, San Francisco | 2002 |
Guttman Lecturer | University of Kentucky | 2000 |
Scientist of the Year | International Pharmaceutical Federation (FIP) | 1999 |
Recognition Award for Distinguished Achievement of a Filipino at UCSF | University of California, San Francisco | 1999 |
Chancellor's Award for the Advancement of Women | University of California, San Francisco | 1997 |
Martin Luther King, Jr. Award for the Advancement of Minorities | University of California, San Francisco | 1994 |
Fogarty International Fellowship | National Institutes of Health | 1992 |
Leon Goldberg Young Investigator Award | American Society for Clinical Pharmacology and Therapeutics | 1990 |
Education
Fellowships
Grants and Funding
- Characterizing the physiological and pharmacological roles of SLC22A24 | NIH | 2021-04-01 - 2025-03-31 | Role: Principal Investigator
- Discovery of Pharmacogenomic Biomarkers for OATP1B1 and OATP1B3 | NIH | 2015-09-25 - 2024-07-31 | Role: Principal Investigator
- UCSF-Stanford Center of Excellence in Regulatory Science and Innovation | NIH | 2016-09-15 - 2023-08-31 | Role: Principal Investigator
- PGRN Administrative Coordination Hub, ACH (PGRN) | NIH/NIGMS | 2015-07-15 - 2020-06-30 | Role: Principal Investigator
- Role of ABCG2 in the disposition and anti-hyperuricemic effects of allopurinol | NIH | 2014-09-20 - 2018-07-31 | Role: Principal Investigator
- UCSF-Stanford Center of Excellence in Regulatory Science and Innovation | NIH | 2014-04-15 - 2017-03-31 | Role: Principal Investigator
- Center for Structure of Membrane Proteins | NIH | 2010-09-30 - 2016-06-30 | Role: Co-Investigator
- Pharmacogenomics of Membrane Transporters | NIH | 2000-04-01 - 2015-06-30 | Role: Principal Investigator
- A Comprehensive Platform for Transporter Mediated Drug-Drug Interaction Studies | NIH | 2009-02-01 - 2013-09-30 | Role: Principal Investigator
- Resource for Biocomputing, Visualization, and Informatics | NIH/NCRR | 1976-06-01 - 2012-09-14 | Role: Co-Investigator
- Cellular Mechanisms of Drug Elimination | NIH | 1986-04-04 - 2012-05-31 | Role: Principal Investigator
- Pharmacogenetics of Membrane Transporters | NIH | 2000-04-01 - 2010-07-14 | Role: Principal Investigator
- General Clinical Research Center | NIH | 1974-12-01 - 2009-03-31 | Role: Co-Investigator
- General Clinical Research Center | NIH | 1974-10-01 - 2007-11-30 | Role: Co-Investigator
- CELLULAR MECHANISMS OF DRUG TRANSPORT IN CHOROID PLEXUS | NIH | 1991-01-01 - 2003-12-31 | Role: Principal Investigator
- MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE | NIH | 1997-08-01 - 2001-07-31 | Role: Principal Investigator
- PHARMACOKINETICS/PHARMACODYNAMICS | NIH | 1979-08-01 - 1998-07-31 | Role: Co-Investigator
- MOLECULAR MECHANISMS OF DRUG TRANSPORT | NIH | 1992-01-01 - | Role: Principal Investigator
- STEREOSELECTIVE PHARMACOKINETICS OF DRUGS IN THE KIDNEY | NIH | 1983-03-01 - 1989-06-30 | Role: Principal Investigator
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 364
- Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier.| | View in PubMed
- Report of the 2023-24 AACP Research and Graduate Affairs Committee.| | View in PubMed
- Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.| | View in PubMed
- Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants.| | View in PubMed
- Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters.| | View in PubMed
- The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.| | View in PubMed
- Structural and molecular basis of choline uptake into the brain by FLVCR2.| | View in PubMed
- Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes.| | View in PubMed
- Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype-Guided Precision Medicine.| | View in PubMed
- Membrane transporters in drug development and as determinants of precision medicine.| | View in PubMed
- Artificial intelligence, ChatGPT, and other large language models for social determinants of health: Current state and future directions.| | View in PubMed
- Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling.| | View in PubMed
- Ensuring Transparency and Quality of Clinical Trial Reporting in Clinical Pharmacology & Therapeutics: Prospective Trial Registration and Compliance with Reporting Guidelines Are Required for all Clinical Trials.| | View in PubMed
- Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.| | View in PubMed
- TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters.| | View in PubMed
- Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.| | View in PubMed
- Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).| | View in PubMed
- The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse.| | View in PubMed
- Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.| | View in PubMed
- Trends in Clinical Pharmacology and Therapeutics.| | View in PubMed
- The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.| | View in PubMed
- The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction.| | View in PubMed
- Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.| | View in PubMed
- Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.| | View in PubMed
- Biomarkers Come of Age in Clinical Pharmacology.| | View in PubMed
- Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All.| | View in PubMed
- Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.| | View in PubMed
- More Than Pharmacokinetics: Transporters in Clinical Pharmacology.| | View in PubMed
- New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.| | View in PubMed
- A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption.| | View in PubMed
- Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682.| | View in PubMed
- The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.| | View in PubMed
- The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology.| | View in PubMed
- High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.| | View in PubMed
- Emerging Roles of the Human Solute Carrier 22 Family.| | View in PubMed
- Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.| | View in PubMed
- Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein.| | View in PubMed
- Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network.| | View in PubMed
- Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data.| | View in PubMed
- Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.| | View in PubMed
- Opportunities and challenges for the computational interpretation of rare variation in clinically important genes.| | View in PubMed
- The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2.| | View in PubMed
- A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring.| | View in PubMed
- Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.| | View in PubMed
- Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.| | View in PubMed
- A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.| | View in PubMed
- Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.| | View in PubMed
- Scientific considerations for global drug development.| | View in PubMed
- The activities of drug inactive ingredients on biological targets.| | View in PubMed
- Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.| | View in PubMed
- COVID-19: A Defining Moment for Clinical Pharmacology?| | View in PubMed
- Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.| | View in PubMed
- Oral Anticoagulants and Precision Medicine: Something Old, Something New.| | View in PubMed
- Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response.| | View in PubMed
- GenEpi: gene-based epistasis discovery using machine learning.| | View in PubMed
- Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.| | View in PubMed
- Clinical Pharmacology & Therapeutics 2030.| | View in PubMed
- Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3).| | View in PubMed
- Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.| | View in PubMed
- Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.| | View in PubMed
- Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.| | View in PubMed
- A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.| | View in PubMed
- A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.| | View in PubMed
- l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.| | View in PubMed
- Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.| | View in PubMed
- Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.| | View in PubMed
- Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.| | View in PubMed
- Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation.| | View in PubMed
- Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters.| | View in PubMed
- Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.| | View in PubMed
- Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium.| | View in PubMed
- The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development.| | View in PubMed
- Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).| | View in PubMed
- Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.| | View in PubMed
- Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium.| | View in PubMed
- ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.| | View in PubMed
- Pharmacogenetics of Antidiabetic Drugs.| | View in PubMed
- Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.| | View in PubMed
- Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.| | View in PubMed
- Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.| | View in PubMed
- Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions.| | View in PubMed
- Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.| | View in PubMed
- PharmGKB summary: very important pharmacogene information for ABCG2.| | View in PubMed
- New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.| | View in PubMed
- PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters.| | View in PubMed
- Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.| | View in PubMed
- Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.| | View in PubMed
- Transporters Involved in Metformin Pharmacokinetics and Treatment Response.| | View in PubMed
- The Effect of Uremic Solutes on the Organic Cation Transporter 2.| | View in PubMed
- Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).| | View in PubMed
- Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.| | View in PubMed
- Genomic Characterization of Metformin Hepatic Response.| | View in PubMed
- Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.| | View in PubMed
- The use of drug transporters as therapeutic targets.| | View in PubMed
- A Molecular Basis for Innovation in Drug Excipients.| | View in PubMed
- A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.| | View in PubMed
- Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.| | View in PubMed
- LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.| | View in PubMed
- Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.| | View in PubMed
- Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.| | View in PubMed
- Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.| | View in PubMed
- Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.| | View in PubMed
- Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.| | View in PubMed
- The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.| | View in PubMed
- A research roadmap for next-generation sequencing informatics.| | View in PubMed
- LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.| | View in PubMed
- The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.| | View in PubMed
- Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.| | View in PubMed
- Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.| | View in PubMed
- Unmet needs: Research helps regulators do their jobs.| | View in PubMed
- Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).| | View in PubMed
- Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.| | View in PubMed
- Prediction and validation of enzyme and transporter off-targets for metformin.| | View in PubMed
- SLC transporters as therapeutic targets: emerging opportunities.| | View in PubMed
- Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.| | View in PubMed
- Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.| | View in PubMed
- Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.| | View in PubMed
- A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.| | View in PubMed
- OCT1 in hepatic steatosis and thiamine disposition.| | View in PubMed
- Genome-wide discovery of drug-dependent human liver regulatory elements.| | View in PubMed
- Metformin pharmacogenomics: current status and future directions.| | View in PubMed
- OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.| | View in PubMed
- PharmGKB summary: very important pharmacogene information for SLC22A1.| | View in PubMed
- Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.| | View in PubMed
- Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype.| | View in PubMed
- Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations.| | View in PubMed
- Profiling solute carrier transporters in the human blood-brain barrier.| | View in PubMed
- A genome-wide association study of bronchodilator response in Latinos implicates rare variants.| | View in PubMed
- International Transporter Consortium commentary on clinically important transporter polymorphisms.| | View in PubMed
- SLC classification: an update.| | View in PubMed
- Transporters in drug development and clinical pharmacology.| | View in PubMed
- Special Section on Pharmacogenomics: recent advances and future directions.| | View in PubMed
- Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.| | View in PubMed
- Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).| | View in PubMed
- Emerging transporters of clinical importance: an update from the International Transporter Consortium.| | View in PubMed
- Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.| | View in PubMed
- Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.| | View in PubMed
- Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.| | View in PubMed
- Molecular modeling and ligand docking for solute carrier (SLC) transporters.| | View in PubMed
- Renal transporters in drug development.| | View in PubMed
- Highlights from the International Transporter Consortium second workshop.| | View in PubMed
- Metformin pathways: pharmacokinetics and pharmacodynamics.| | View in PubMed
- The UCSF-FDA TransPortal: a public drug transporter database.| | View in PubMed
- The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.| | View in PubMed
- Pharmacogenomics and patient care: one size does not fit all.| | View in PubMed
- Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.| | View in PubMed
- High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.| | View in PubMed
- Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong!| | View in PubMed
- The role of ATM in response to metformin treatment and activation of AMPK.| | View in PubMed
- Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3.| | View in PubMed
- Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.| | View in PubMed
- A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.| | View in PubMed
- PharmGKB summary: methotrexate pathway.| | View in PubMed
- A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.| | View in PubMed
- Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.| | View in PubMed
- Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.| | View in PubMed
- Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.| | View in PubMed
- Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.| | View in PubMed
- Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.| | View in PubMed
- Functional characterization of liver enhancers that regulate drug-associated transporters.| | View in PubMed
- Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins.| | View in PubMed
- GABAA receptor open-state conformation determines non-competitive antagonist binding.| | View in PubMed
- Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.| | View in PubMed
- Consequences of POR mutations and polymorphisms.| | View in PubMed
- Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.| | View in PubMed
- Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.| | View in PubMed
- SLC19A1 pharmacogenomics summary.| | View in PubMed
- Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.| | View in PubMed
- Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.| | View in PubMed
- Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.| | View in PubMed
- Role of the copper transporter, CTR1, in platinum-induced ototoxicity.| | View in PubMed
- Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.| | View in PubMed
- Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.| | View in PubMed
- Pharmacogenomics of membrane transporters: past, present and future.| | View in PubMed
- Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.| | View in PubMed
- Comparison of human solute carriers.| | View in PubMed
- Membrane transporters in drug development.| | View in PubMed
- The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA.| | View in PubMed
- The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.| | View in PubMed
- Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.| | View in PubMed
- The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.| | View in PubMed
- Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.| | View in PubMed
- Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy.| | View in PubMed
- A survey of integral alpha-helical membrane proteins.| | View in PubMed
- Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.| | View in PubMed
- Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.| | View in PubMed
- The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.| | View in PubMed
- Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.| | View in PubMed
- Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).| | View in PubMed
- Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).| | View in PubMed
- Identification and characterization of 3-iodothyronamine intracellular transport.| | View in PubMed
- Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.| | View in PubMed
- Genetic variation in human P450 oxidoreductase.| | View in PubMed
- Genetic variation in human aquaporins and effects on phenotypes of water homeostasis.| | View in PubMed
- Pharm. D. pathways to biomedical research: the National Institutes of Health special conference on pharmacy research.| | View in PubMed
- cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.| | View in PubMed
- Creating and evaluating genetic tests predictive of drug response.| | View in PubMed
- Genetic variation in drug transporters in ethnic populations.| | View in PubMed
- Novel variants in human Aquaporin-4 reduce cellular water permeability.| | View in PubMed
- Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system.| | View in PubMed
- The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.| | View in PubMed
- Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations.| | View in PubMed
- Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.| | View in PubMed
- Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.| | View in PubMed
- Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4).| | View in PubMed
- Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.| | View in PubMed
- Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.| | View in PubMed
- Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.| | View in PubMed
- Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.| | View in PubMed
- Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.| | View in PubMed
- When good drugs go bad.| | View in PubMed
- The pharmacogenetics research network: from SNP discovery to clinical drug response.| | View in PubMed
- Pharmacogenomics: challenges and opportunities.| | View in PubMed
- Organic cation transporters are determinants of oxaliplatin cytotoxicity.| | View in PubMed
- Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).| | View in PubMed
- Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2.| | View in PubMed
- Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.| | View in PubMed
- PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.| | View in PubMed
- PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.| | View in PubMed
- PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.| | View in PubMed
- Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.| | View in PubMed
- Functional genomics of membrane transporters in human populations.| | View in PubMed
- The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.| | View in PubMed
- Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.| | View in PubMed
- Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).| | View in PubMed
- Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.| | View in PubMed
- Enhancing data sharing in collaborative research projects with DASH.| | View in PubMed
- Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3).| | View in PubMed
- Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease.| | View in PubMed
- PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1.| | View in PubMed
- Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.| | View in PubMed
- Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney.| | View in PubMed
- Estimating the contribution of genes and environment to variation in renal drug clearance.| | View in PubMed
- Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.| | View in PubMed
- PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2).| | View in PubMed
- The concentrative nucleoside transporter family, SLC28.| | View in PubMed
- Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1.| | View in PubMed
- Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.| | View in PubMed
- Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.| | View in PubMed
- Sorting of rat SPNT in renal epithelium is independent of N-glycosylation.| | View in PubMed
- Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.| | View in PubMed
- SNP analysis and presentation in the Pharmacogenetics of Membrane Transporters Project.| | View in PubMed
- Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).| | View in PubMed
- Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT.| | View in PubMed
- Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition.| | View in PubMed
- Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.| | View in PubMed
- Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells.| | View in PubMed
- Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.| | View in PubMed
- Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line.| | View in PubMed
- Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes.| | View in PubMed
- Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters.| | View in PubMed
- A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans.| | View in PubMed
- Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes.| | View in PubMed
- Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine.| | View in PubMed
- Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.| | View in PubMed
- Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1).| | View in PubMed
- Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system.| | View in PubMed
- The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1.| | View in PubMed
- Characterization of a bioengineered chimeric Na+-nucleoside transporter.| | View in PubMed
- Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter.| | View in PubMed
- Molecular and functional characteristics of cloned human organic cation transporters.| | View in PubMed
- Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).| | View in PubMed
- Nucleoside transport in isolated human and rhesus choroid plexus tissue slices.| | View in PubMed
- Nicotine transport in a human choriocarcinoma cell line (JAR).| | View in PubMed
- Molecular cloning and functional expression of a rabbit renal organic cation transporter.| | View in PubMed
- Role of organic cation transporters in drug absorption and elimination.| | View in PubMed
- Membrane transporters in drug disposition.| | View in PubMed
- Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.| | View in PubMed
- Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters.| | View in PubMed
- Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit.| | View in PubMed
- Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.| | View in PubMed
- Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa).| | View in PubMed
- Characterization of guanidine transport in human renal brush border membranes.| | View in PubMed
- Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).| | View in PubMed
- Cloning and functional expression of a human liver organic cation transporter.| | View in PubMed
- Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes.| | View in PubMed
- Guanidine transport in a human choriocarcinoma cell line (JAR).| | View in PubMed
- Taurine transport in cultured choroid plexus.| | View in PubMed
- Mechanisms of 5-fluorouracil (5-FU) transport in isolated rabbit choroid plexus tissue slices.| | View in PubMed
- Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport.| | View in PubMed
- Saturable disposition of taurine in the rat cerebrospinal fluid.| | View in PubMed
- Isolated renal brush border and basolateral membrane vesicles and cultured renal cells.| | View in PubMed
- Methods of study drug transport in isolated choroid plexus tissue and cultured cells.| | View in PubMed
- Mechanisms of nucleobase transport in rabbit choroid plexus. Evidence for a Na(+)-dependent nucleobase transporter with broad substrate selectivity.| | View in PubMed
- The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus.| | View in PubMed
- The effects of modulation of calcium influx through the voltage-sensitive calcium channel on cardiomyocyte hypertrophy.| | View in PubMed
- Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes.| | View in PubMed
- Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy.| | View in PubMed
- Expression of the choroid plexus sodium-nucleoside cotransporter (N3) in Xenopus laevis oocytes.| | View in PubMed
- Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus.| | View in PubMed
- Expression of a renal Na(+)-nucleoside cotransport system (N2) in Xenopus laevis oocytes.| | View in PubMed
- Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit.| | View in PubMed
- Effect of phenylisothiocyanate on organic cation transport in opossum kidney cells.| | View in PubMed
- Stereoselective interactions of organic cations with the organic cation transporter in OK cells.| | View in PubMed
- Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney.| | View in PubMed
- Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine.| | View in PubMed
- Formycin B elimination from the cerebrospinal fluid of the rat.| | View in PubMed
- Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney.| | View in PubMed
- Caring for the community| | View in PubMed
- Beta-adrenergic blockers as cardioprotective agents.| | View in PubMed
- Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction.| | View in PubMed
- Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides.| | View in PubMed
- Nucleoside transport in brush border membrane vesicles from human kidney.| | View in PubMed
- Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells.| | View in PubMed
- Organic cation transport in human renal brush-border membrane vesicles.| | View in PubMed
- Transport of organic cations by a renal epithelial cell line (OK).| | View in PubMed
- Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide.| | View in PubMed
- Preparation of brush border membrane vesicles from bovine choroid plexus.| | View in PubMed
- Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles.| | View in PubMed
- Cimetidine transport in isolated brush border membrane vesicles from bovine choroid plexus.| | View in PubMed
- Mechanisms of interactions between organic anions and the organic cation transporter in renal brush border membrane vesicles.| | View in PubMed
- Computer-guided laser for neurosurgery.| | View in PubMed
- The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose.| | View in PubMed
- High-performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. II. Studies with atenolol.| | View in PubMed
- The effect of probenecid on the renal elimination of cimetidine.| | View in PubMed
- The pharmacokinetics of the enantiomers of atenolol.| | View in PubMed
- Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium.| | View in PubMed
- Cimetidine elimination from the cerebrospinal fluid of the rat.| | View in PubMed
- Renal transport of drugs: an overview of methodology with application to cimetidine.| | View in PubMed
- Stereoselective binding of disopyramide to plasma proteins.| | View in PubMed
- The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles.| | View in PubMed
- Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney.| | View in PubMed
- Interactions of organic anions with the organic cation transporter in renal BBMV.| | View in PubMed
- Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium.| | View in PubMed
- Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney.| | View in PubMed
- Essential tyrosine residues in transport of organic cations in renal BBMV.| | View in PubMed
- The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange.| | View in PubMed
- Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil.| | View in PubMed
- The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.| | View in PubMed
- In vivo interaction of the enantiomers of disopyramide in human subjects.| | View in PubMed
- Posttraumatic complications and inflammatory mediators.| | View in PubMed
- High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol.| | View in PubMed
- Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel.| | View in PubMed
- Stereoselective renal clearance of pindolol in humans.| | View in PubMed
- Electrophysiology of the enantiomers of disopyramide in dogs.| | View in PubMed
- The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits.| | View in PubMed
- Verapamil interacts stereoselectively with the muscarinic receptor.| | View in PubMed
- Decreased binding of verapamil to plasma proteins in patients with liver disease.| | View in PubMed
- Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration.| | View in PubMed
- High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma.| | View in PubMed
- Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide.| | View in PubMed
- Amitriptyline disposition in young and elderly normal men.| | View in PubMed
- Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin.| | View in PubMed
- Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man.| | View in PubMed
- Calculation of drug concentration in plasma after equilibrium dialysis.| | View in PubMed
- The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study.| | View in PubMed
- High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood.| | View in PubMed
- Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography.| | View in PubMed
- The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide.| | View in PubMed
- Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.| | View in PubMed
- Evaluation of methods for producing renal dysfunction in rats.| | View in PubMed
- Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins.| | View in PubMed
- The stereoselective disposition of disopyramide in the dog.| | View in PubMed
- Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum.| | View in PubMed
- Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma.| | View in PubMed
- Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt.| | View in PubMed
- Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs.| | View in PubMed
- Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient.| | View in PubMed
- Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients.| | View in PubMed
- Phenylalanine metabolism in uremic and normal man.| | View in PubMed
- Rational aspirin dosage regimens.| | View in PubMed
- Plasma protein binding of d-propoxyphene in normal subjects and anephric patients.| | View in PubMed
- A Convenient Method for Repetitive Blood Sampling in the Dog| | View in PubMed
- [Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease].| | View in PubMed