University of California San Francisco

Kathy Giacomini, PhD
Kathy Giacomini, PhD

Professor, Bioengineering
Co-Director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation

Address

513 Parnassus Avenue, MSB, #126
San Francisco, CA 94143
United States

Email: [email protected]
Phone: 415-476-8010
Fax: 415-514-4361

ORCID: 0000-0001-8041-5430

Awards & Honors

Award Conferred By Date
Elected Member American Academy of Arts and Sciences 2024
Elected Fellow American Society for Clinical Pharmacology and Experimental Therapeutics 2024
Oscar B. Hunt Career Award in Therapeutics American Society for Clinical Pharmacology and Experimental Therapeutics 2024
Reynold Spector Award in Clinical Pharmacology American Society for Pharmacology and Experimental Therapeutics 2023
Willis G. Gregory Memorial Award University of Buffalo School of Pharmacy & Pharmaceutical Sciences 2023
Distinguished Pharmaceutical Scientist Award American Association of Pharmaceutical Scientists 2021
B.B. Brodie Award American Society of Pharmacology and Experimental Therapeutics 2020
Volwiler Research Achievement Award American Association of Colleges of Pharmacy 2018
Scheele Award Swedish Academy of Pharmaceutical Scientists 2011
Therapeutic Frontiers Lecture Award Therapeutic Frontiers Lecture Award 2010
Rawls-Palmer Progress in Medicine Award American Society for Clinical Pharmacology and Therapeutics 2009
Outstanding Mentor Award Postdoctoral Scholars Association, University of California, San Francisco 2009
Invitation Fellowship Program for Research in Japan Japan Society for the Promotion of Science 2008
International Woman Scientist Award Academy of Pharmaceutical Sciences and Technology, Japan 2007
Research Achievement Award Pharmaceutical Sciences World Congress 2007
Distinguished Scientist Award in Drug Metabolism American Association of Pharmaceutical Scientists 2006
Elected Member National Academy of Medicine 2006
Paul Dawson Biotechnology Award American Association of Colleges of Pharmacy 2005
Distinguished Gerhard Levy Lectureship State University of New York at Buffalo 2002
Distinguished Bill Abram's Lectureship U.S. Food and Drug Administration 2002
Honored Celebrating Women Faculty University of California, San Francisco 2002
Guttman Lecturer University of Kentucky 2000
Scientist of the Year International Pharmaceutical Federation (FIP) 1999
Recognition Award for Distinguished Achievement of a Filipino at UCSF University of California, San Francisco 1999
Chancellor's Award for the Advancement of Women University of California, San Francisco 1997
Martin Luther King, Jr. Award for the Advancement of Minorities University of California, San Francisco 1994
Fogarty International Fellowship National Institutes of Health 1992
Leon Goldberg Young Investigator Award American Society for Clinical Pharmacology and Therapeutics 1990

Grants and Funding

  • Transporter Elucidation Center at the University of California, San Francisco | NIH | 2023-09-19 - 2028-06-30 | Role: Co-Investigator
  • Characterizing the physiological and pharmacological roles of SLC22A24 | NIH | 2021-04-01 - 2025-03-31 | Role: Principal Investigator
  • Discovery of Pharmacogenomic Biomarkers for OATP1B1 and OATP1B3 | NIH | 2015-09-25 - 2024-07-31 | Role: Principal Investigator
  • UCSF-Stanford Center of Excellence in Regulatory Science and Innovation | NIH | 2016-09-15 - 2023-08-31 | Role: Principal Investigator
  • PGRN Administrative Coordination Hub, ACH (PGRN) | NIH/NIGMS | 2015-07-15 - 2020-06-30 | Role: Principal Investigator
  • Role of ABCG2 in the disposition and anti-hyperuricemic effects of allopurinol | NIH | 2014-09-20 - 2018-07-31 | Role: Principal Investigator
  • UCSF-Stanford Center of Excellence in Regulatory Science and Innovation | NIH | 2014-04-15 - 2017-03-31 | Role: Principal Investigator
  • Center for Structure of Membrane Proteins | NIH | 2010-09-30 - 2016-06-30 | Role: Co-Investigator
  • Pharmacogenomics of Membrane Transporters | NIH | 2000-04-01 - 2015-06-30 | Role: Principal Investigator
  • A Comprehensive Platform for Transporter Mediated Drug-Drug Interaction Studies | NIH | 2009-02-01 - 2013-09-30 | Role: Principal Investigator
  • Resource for Biocomputing, Visualization, and Informatics | NIH/NCRR | 1976-06-01 - 2012-09-14 | Role: Co-Investigator
  • Cellular Mechanisms of Drug Elimination | NIH | 1986-04-04 - 2012-05-31 | Role: Principal Investigator
  • Pharmacogenetics of Membrane Transporters | NIH | 2000-04-01 - 2010-07-14 | Role: Principal Investigator
  • General Clinical Research Center | NIH | 1974-12-01 - 2009-03-31 | Role: Co-Investigator
  • General Clinical Research Center | NIH | 1974-10-01 - 2007-11-30 | Role: Co-Investigator
  • CELLULAR MECHANISMS OF DRUG TRANSPORT IN CHOROID PLEXUS | NIH | 1991-01-01 - 2003-12-31 | Role: Principal Investigator
  • MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE | NIH | 1997-08-01 - 2001-07-31 | Role: Principal Investigator
  • PHARMACOKINETICS/PHARMACODYNAMICS | NIH | 1979-08-01 - 1998-07-31 | Role: Co-Investigator
  • MOLECULAR MECHANISMS OF DRUG TRANSPORT | NIH | 1992-01-01 - | Role: Principal Investigator
  • STEREOSELECTIVE PHARMACOKINETICS OF DRUGS IN THE KIDNEY | NIH | 1983-03-01 - 1989-06-30 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 371
  1. High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
    Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM| | PubMed
  2. Emerging Roles of the Human Solute Carrier 22 Family.
    Yee SW, Giacomini KM| | PubMed
  3. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.
    Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium, MetGen Plus investigators:| | PubMed
  4. Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein.
    Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL| | PubMed
  5. Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network.
    Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M| | PubMed
  6. Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data.
    Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM| | PubMed
  7. Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.
    Vora B, Brackman DJ, Zou L, Garcia-Cremades M, Sirota M, Savic RM, Giacomini KM| | PubMed
  8. Opportunities and challenges for the computational interpretation of rare variation in clinically important genes.
    McInnes G, Sharo AG, Koleske ML, Brown JEH, Norstad M, Adhikari AN, Wang S, Brenner SE, Halpern J, Koenig BA, Magnus DC, Gallagher RC, Giacomini KM, Altman RB| | PubMed
  9. The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2.
    Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D, Sirota M, Giacomini KM| | PubMed
  10. A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring.
    Lavertu A, Vora B, Giacomini KM, Altman R, Rensi S| | PubMed
371
View all 371 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 371
  1. MRI Provides New Insights Into the Pharmacologic Mechanism of Bisacodyl: A Blueprint for Understanding Intestinal Drug Mechanisms.
    Giacomini KM| | PubMed
  2. Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2).
    Riselli AM, Yee SW, Yang J, Brett CM, Trumbach K, Zhou X, Liu R, Liang X, Lai Y, Huo R, Xue Y, Shen H, Zhang L, Yang X, Liu Q, Huang SM, Giacomini KM| | PubMed
  3. Therapeutic Orphan No More: Role for Clinical Pharmacology and Translational Science in Developing Therapeutics for Rare and Neglected Diseases.
    Ramamoorthy A, Younis I, Wen YF, Mehanna M, Giacomini KM, van der Graaf PH| | PubMed
  4. Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout.
    Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK, Shirai Y, Wang W, Cadzow MJ, Phipps-Green AJ, Li Z, Ji A, Merriman ME, Morice E, Kelley EE, Wei WH, McCormick SPA, Bixley MJ, Reynolds RJ, Saag KG, Fadason T, Golovina E, O'Sullivan JM, Stamp LK, Dalbeth N, Abhishek A, Doherty M, Roddy E, Jacobsson LTH, Kapetanovic MC, Melander O, Andrés M, Pérez-Ruiz F, Torres RJ, Radstake T, Jansen TL, Janssen M, Joosten LAB, Liu R, Gaal OI, Crisan TO, Rednic S, Kurreeman F, Huizinga TWJ, Toes R, Lioté F, Richette P, Bardin T, Ea HK, Pascart T, McCarthy GM, Helbert L, Stiburková B, Tausche AK, Uhlig T, Vitart V, Boutin TS, Hayward C, Riches PL, Ralston SH, Campbell A, MacDonald TM, FAST Study Group, Nakayama A, Takada T, Nakatochi M, Shimizu S, Kawamura Y, Toyoda Y, Nakaoka H, Yamamoto K, Matsuo K, Shinomiya N, Ichida K, Japan Gout Genomics Consortium, Lee C, Asia Pacific Gout Consortium, Bradbury LA, Brown MA, Robinson PC, Buchanan RRC, Hill CL, Lester S, Smith MD, Rischmueller M, Choi HK, Stahl EA, Miner JN, Solomon DH, Cui J, Giacomini KM, Brackman DJ, Jorgenson EM, GlobalGout Genetics Consortium, Liu H, Susztak K, 23andMe Research Team, Shringarpure S, So A, Okada Y, Li C, Shi Y, Merriman TR| | PubMed
  5. A genome-wide association analysis reveals new pathogenic pathways in gout.
    Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK, Shirai Y, Wang W, Cadzow MJ, Phipps-Green AJ, Li Z, Ji A, Merriman ME, Morice E, Kelley EE, Wei WH, McCormick SPA, Bixley MJ, Reynolds RJ, Saag KG, Fadason T, Golovina E, O'Sullivan JM, Stamp LK, Dalbeth N, Abhishek A, Doherty M, Roddy E, Jacobsson LTH, Kapetanovic MC, Melander O, Andrés M, Pérez-Ruiz F, Torres RJ, Radstake T, Jansen TL, Janssen M, Joosten LAB, Liu R, Gaal OI, Crisan TO, Rednic S, Kurreeman F, Huizinga TWJ, Toes R, Lioté F, Richette P, Bardin T, Ea HK, Pascart T, McCarthy GM, Helbert L, Stiburková B, Tausche AK, Uhlig T, Vitart V, Boutin TS, Hayward C, Riches PL, Ralston SH, Campbell A, MacDonald TM, FAST Study Group, Nakayama A, Takada T, Nakatochi M, Shimizu S, Kawamura Y, Toyoda Y, Nakaoka H, Yamamoto K, Matsuo K, Shinomiya N, Ichida K, Japan Gout Genomics Consortium, Lee C, Asia Pacific Gout Consortium, Bradbury LA, Brown MA, Robinson PC, Buchanan RRC, Hill CL, Lester S, Smith MD, Rischmueller M, Choi HK, Stahl EA, Miner JN, Solomon DH, Cui J, Giacomini KM, Brackman DJ, Jorgenson EM, GlobalGout Genetics Consortium, Liu H, Susztak K, 23andMe Research Team, Shringarpure S, So A, Okada Y, Li C, Shi Y, Merriman TR| | PubMed
  6. Is Pharmacogenetic Testing a Vital Tool for Enhancing Therapeutic Management of Patients Worldwide?
    Giacomini KM, van der Graaf PH| | PubMed
  7. Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood-Brain Barrier.
    Yee SW, Wang J, Giacomini KM| | PubMed
  8. Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier.
    Zhou X, Azimi M, Handin N, Riselli A, Vora B, Chun E, Yee SW, Artursson P, Giacomini KM| | PubMed
  9. Report of the 2023-2024 AACP Research and Graduate Affairs Committee.
    Patterson ME, Ellingrod VL, Feola DJ, Kunda NK, Mei KC, Oestreich JH, Farrell DF, Giacomini KM| | PubMed
  10. Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.
    Yee SW, Ferrández-Peral L, Alentorn-Moron P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Wolfreys FD, Yang J, Gestwicki JE, Capra JA, Artursson P, Newman JW, Marquès-Bonet T, Giacomini KM| | PubMed
  11. Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants.
    Silva DB, Trinidad M, Ljungdahl A, Revalde JL, Berguig GY, Wallace W, Patrick CS, Bomba L, Arkin M, Dong S, Estrada K, Hutchinson K, LeBowitz JH, Schlessinger A, Johannesen KM, Møller RS, Giacomini KM, Froelich S, Sanders SJ, Wuster A| | PubMed
  12. Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters.
    Kulkarni CP, Yang J, Koleske ML, Lara G, Alam K, Raw A, Rege B, Zhao L, Lu D, Zhang L, Yu LX, Lionberger RA, Giacomini KM, Kroetz DL, Yee SW| | PubMed
  13. The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.
    Yee SW, Macdonald CB, Mitrovic D, Zhou X, Koleske ML, Yang J, Buitrago Silva D, Rockefeller Grimes P, Trinidad DD, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W| | PubMed
  14. Structural and molecular basis of choline uptake into the brain by FLVCR2.
    Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, Giacomini KM, Kossiakoff AA, Quick M, Arnold T, Mancia F| | PubMed
  15. Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes.
    Wu B, Yee SW, Xiao S, Xu F, Sridhar SB, Yang M, Hochstadt S, Cabral W, Lanfear DE, Hedderson MM, Giacomini KM, Williams LK| | PubMed
  16. Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype-Guided Precision Medicine.
    Zhao L, Giacomini KM, van der Graaf PH| | PubMed
  17. Membrane transporters in drug development and as determinants of precision medicine.
    Galetin A, Brouwer KLR, Tweedie D, Yoshida K, Sjöstedt N, Aleksunes L, Chu X, Evers R, Hafey MJ, Lai Y, Matsson P, Riselli A, Shen H, Sparreboom A, Varma MVS, Yang J, Yang X, Yee SW, Zamek-Gliszczynski MJ, Zhang L, Giacomini KM| | PubMed
  18. Artificial intelligence, ChatGPT, and other large language models for social determinants of health: Current state and future directions.
    Ong JCL, Seng BJJ, Law JZF, Low LL, Kwa ALH, Giacomini KM, Ting DSW| | PubMed
  19. Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling.
    Hunt JP, Dubinsky S, McKnite AM, Cheung KWK, van Groen BD, Giacomini KM, de Wildt SN, Edginton AN, Watt KM| | PubMed
  20. Ensuring Transparency and Quality of Clinical Trial Reporting in Clinical Pharmacology & Therapeutics: Prospective Trial Registration and Compliance with Reporting Guidelines Are Required for all Clinical Trials.
    Smith DM, Minichmayr IK, Standing JF, Giacomini KM, van der Graaf PH, Peck RW| | PubMed
  21. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
    Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM| | PubMed
  22. TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters.
    Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT| | PubMed
  23. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
    Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM| | PubMed
  24. Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
    Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group:| | PubMed
  25. The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse.
    Wen A, Zhu Y, Yee SW, Park BI, Giacomini KM, Greenberg AS, Newman JW| | PubMed
  26. Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.
    Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R| | PubMed
  27. Trends in Clinical Pharmacology and Therapeutics.
    Minichmayr IK, Smith DM, Giacomini KM, van der Graaf PH| | PubMed
  28. The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
    Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W| | PubMed
  29. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction.
    Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM| | PubMed
  30. Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.
    Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson ER, Yee SW, Giacomini KM, Pollin T, Florez JC| | PubMed
  31. Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.
    Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM| | PubMed
  32. Biomarkers Come of Age in Clinical Pharmacology.
    Giacomini KM| | PubMed
  33. Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All.
    Venkatakrishnan K, Brown KE, Giacomini KM, van der Graaf PH| | PubMed
  34. Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.
    Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM| | PubMed
  35. More Than Pharmacokinetics: Transporters in Clinical Pharmacology.
    Giacomini KM, Huang SM| | PubMed
  36. New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
    Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X| | PubMed
  37. A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption.
    Martinez MN, Sinko B, Wu F, Flanagan T, Borbás E, Tsakalozou E, Giacomini KM| | PubMed
  38. Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682.
    Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium| | PubMed
  39. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
    Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D| | PubMed
  40. The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology.
    Giacomini KM, van der Graaf PH| | PubMed
  41. High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
    Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM| | PubMed
  42. Emerging Roles of the Human Solute Carrier 22 Family.
    Yee SW, Giacomini KM| | PubMed
  43. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.
    Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium, MetGen Plus investigators:| | PubMed
  44. Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein.
    Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL| | PubMed
  45. Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network.
    Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M| | PubMed
  46. Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data.
    Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM| | PubMed
  47. Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.
    Vora B, Brackman DJ, Zou L, Garcia-Cremades M, Sirota M, Savic RM, Giacomini KM| | PubMed
  48. Opportunities and challenges for the computational interpretation of rare variation in clinically important genes.
    McInnes G, Sharo AG, Koleske ML, Brown JEH, Norstad M, Adhikari AN, Wang S, Brenner SE, Halpern J, Koenig BA, Magnus DC, Gallagher RC, Giacomini KM, Altman RB| | PubMed
  49. The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2.
    Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D, Sirota M, Giacomini KM| | PubMed
  50. A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring.
    Lavertu A, Vora B, Giacomini KM, Altman R, Rensi S| | PubMed
  51. Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.
    Neul C, Hofmann U, Schaeffeler E, Winter S, Klein K, Giacomini KM, Eichelbaum M, Schwab M, Nies AT| | PubMed
  52. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
    Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM| | PubMed
  53. A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.
    Matsson P, Baranczewski P, Giacomini KM, Andersson TB, Palm J, Palm K, Charman WN, Bergström CAS| | PubMed
  54. Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
    Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM| | PubMed
  55. Scientific considerations for global drug development.
    Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, Lumpkin MM, Giacomini KM, Blaschke TF| | PubMed
  56. The activities of drug inactive ingredients on biological targets.
    Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, Berg EL, Giacomini KM, Roth BL, Shoichet BK, Urban L| | PubMed
  57. Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.
    Lin L, Lemieux GA, Enogieru OJ, Giacomini KM, Ashrafi K| | PubMed
  58. COVID-19: A Defining Moment for Clinical Pharmacology?
    van der Graaf PH, Giacomini KM| | PubMed
  59. Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.
    Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, Turnbaugh PJ| | PubMed
  60. Oral Anticoagulants and Precision Medicine: Something Old, Something New.
    Shahin MH, Giacomini KM| | PubMed
  61. Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response.
    Giacomini KM| | PubMed
  62. GenEpi: gene-based epistasis discovery using machine learning.
    Chang YC, Wu JT, Hong MY, Tung YA, Hsieh PH, Yee SW, Giacomini KM, Oyang YJ, Chen CY, Alzheimer’s Disease Neuroimaging Initiative| | PubMed
  63. Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.
    Zou L, Pottel J, Khuri N, Ngo HX, Ni Z, Tsakalozou E, Warren MS, Huang Y, Shoichet BK, Giacomini KM| | PubMed
  64. Clinical Pharmacology & Therapeutics 2030.
    van der Graaf PH, Giacomini KM| | PubMed
  65. Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3).
    Vora B, Green EAE, Khuri N, Ballgren F, Sirota M, Giacomini KM| | PubMed
  66. Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.
    Yee SW, Do TP, Huang SM, Krauss RM, Kusuhara H, Sugiyama Y, Unadkat JD, Giacomini KM| | PubMed
  67. Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.
    Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF| | PubMed
  68. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.
    Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM| | PubMed
  69. A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
    Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P| | PubMed
  70. A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.
    Cheung KWK, van Groen BD, Spaans E, van Borselen MD, de Bruijn ACJM, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN| | PubMed
  71. l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.
    Hall C, Wolfe H, Wells A, Chien HC, Colas C, Schlessinger A, Giacomini KM, Thomas AA| | PubMed
  72. Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
    Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM| | PubMed
  73. Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.
    Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM| | PubMed
  74. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.
    Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM| | PubMed
  75. Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation.
    Giacomini KM, Lin L, Altman RB| | PubMed
  76. Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters.
    Zou L, Ni Z, Tsakalozou E, Giacomini KM| | PubMed
  77. Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.
    Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L| | PubMed
  78. Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium.
    Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L, International Transporter Consortium| | PubMed
  79. The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development.
    Giacomini KM, Galetin A, Huang SM| | PubMed
  80. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
    Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA| | PubMed
  81. Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
    Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y, International Transporter Consortium| | PubMed
  82. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium.
    Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM| | PubMed
  83. ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.
    Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L, International Transporter Consortium| | PubMed
  84. Pharmacogenetics of Antidiabetic Drugs.
    Srinivasan S, Yee SW, Giacomini KM| | PubMed
  85. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
    Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM| | PubMed
  86. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
    Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM| | PubMed
  87. Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.
    Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA, MetGen Investigators, ACCORD/ACCORDion Investigators| | PubMed
  88. Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions.
    Zamek-Gliszczynski MJ, Giacomini KM, Zhang L| | PubMed
  89. Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
    Brackman DJ, Giacomini KM| | PubMed
  90. PharmGKB summary: very important pharmacogene information for ABCG2.
    Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE| | PubMed
  91. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.
    Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM| | PubMed
  92. PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters.
    Hsueh CH, Hsu V, Zhao P, Zhang L, Giacomini KM, Huang SM| | PubMed
  93. Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.
    Stecula A, Schlessinger A, Giacomini KM, Sali A| | PubMed
  94. Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.
    Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM| | PubMed
  95. Transporters Involved in Metformin Pharmacokinetics and Treatment Response.
    Liang X, Giacomini KM| | PubMed
  96. The Effect of Uremic Solutes on the Organic Cation Transporter 2.
    Cheung KWK, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM| | PubMed
  97. Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
    Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM| | PubMed
  98. Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.
    Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen MM, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, Klimcáková L, Pirags V, Kooy A, Brøsen K, Klovins J, Semiz S, Tkác I, Stricker BH, Palmer C, 't Hart LM, Giacomini KM, Pearson ER| | PubMed
  99. Genomic Characterization of Metformin Hepatic Response.
    Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N| | PubMed
  100. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.
    Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M| | PubMed
  101. The use of drug transporters as therapeutic targets.
    Giacomini KM| | PubMed
  102. A Molecular Basis for Innovation in Drug Excipients.
    Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM| | PubMed
  103. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
    Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM| | PubMed
  104. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.
    Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM| | PubMed
  105. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.
    Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA| | PubMed
  106. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.
    Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM| | PubMed
  107. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
    Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER| | PubMed
  108. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
    Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M| | PubMed
  109. Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
    Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Parisi MT, Shulkin BL, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG| | PubMed
  110. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.
    Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R| | PubMed
  111. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.
    Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM| | PubMed
  112. A research roadmap for next-generation sequencing informatics.
    Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T| | PubMed
  113. LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.
    Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA| | PubMed
  114. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.
    Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM| | PubMed
  115. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
    Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE| | PubMed
  116. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.
    Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM| | PubMed
  117. Unmet needs: Research helps regulators do their jobs.
    Altman RB, Khuri N, Salit M, Giacomini KM| | PubMed
  118. Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
    Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM| | PubMed
  119. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
    Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG| | PubMed
  120. Prediction and validation of enzyme and transporter off-targets for metformin.
    Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM| | PubMed
  121. SLC transporters as therapeutic targets: emerging opportunities.
    Lin L, Yee SW, Kim RB, Giacomini KM| | PubMed
  122. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
    Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM| | PubMed
  123. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
    Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM| | PubMed
  124. Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.
    DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao-Wei D, Villablanca JG, Marachelian A, Matthay KK| | PubMed
  125. A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.
    Dahlin A, Wittwer M, de la Cruz M, Woo JM, Bam R, Scharen-Guivel V, Flaherty J, Ray AS, Cihlar T, Gupta SK, Giacomini KM| | PubMed
  126. OCT1 in hepatic steatosis and thiamine disposition.
    Chen L, Yee SW, Giacomini KM| | PubMed
  127. Genome-wide discovery of drug-dependent human liver regulatory elements.
    Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N| | PubMed
  128. Metformin pharmacogenomics: current status and future directions.
    Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC| | PubMed
  129. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
    Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM| | PubMed
  130. PharmGKB summary: very important pharmacogene information for SLC22A1.
    Goswami S, Gong L, Giacomini K, Altman RB, Klein TE| | PubMed
  131. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
    Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM| | PubMed
  132. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype.
    Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM, Clinical Pharmacogenetics Implementation Consortium| | PubMed
  133. Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations.
    Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini KM, Huang SM| | PubMed
  134. Profiling solute carrier transporters in the human blood-brain barrier.
    Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM| | PubMed
  135. A genome-wide association study of bronchodilator response in Latinos implicates rare variants.
    Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG| | PubMed
  136. International Transporter Consortium commentary on clinically important transporter polymorphisms.
    Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M, International Transporter Consortium| | PubMed
  137. SLC classification: an update.
    Schlessinger A, Yee SW, Sali A, Giacomini KM| | PubMed
  138. Transporters in drug development and clinical pharmacology.
    Giacomini KM, Huang SM| | PubMed
  139. Special Section on Pharmacogenomics: recent advances and future directions.
    Mushiroda T, Giacomini KM, Kubo M| | PubMed
  140. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.
    Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C| | PubMed
  141. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).
    Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM| | PubMed
  142. Emerging transporters of clinical importance: an update from the International Transporter Consortium.
    Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L, International Transporter Consortium| | PubMed
  143. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.
    Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM| | PubMed
  144. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.
    Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM| | PubMed
  145. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
    Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM| | PubMed
  146. Molecular modeling and ligand docking for solute carrier (SLC) transporters.
    Schlessinger A, Khuri N, Giacomini KM, Sali A| | PubMed
  147. Renal transporters in drug development.
    Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM| | PubMed
  148. Highlights from the International Transporter Consortium second workshop.
    Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM| | PubMed
  149. Metformin pathways: pharmacokinetics and pharmacodynamics.
    Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE| | PubMed
  150. The UCSF-FDA TransPortal: a public drug transporter database.
    Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM| | PubMed
  151. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.
    Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM| | PubMed
  152. Pharmacogenomics and patient care: one size does not fit all.
    Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y| | PubMed
  153. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
    Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK| | PubMed
  154. High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.
    Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A| | PubMed
  155. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong!
    Smith DE, Rowland M, Giacomini KM, Amidon GL| | PubMed
  156. The role of ATM in response to metformin treatment and activation of AMPK.
    Yee SW, Chen L, Giacomini KM| | PubMed
  157. Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3.
    Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini KM| | PubMed
  158. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
    Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV| | PubMed
  159. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
    Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, Nakamura Y, Ratain MJ| | PubMed
  160. PharmGKB summary: methotrexate pathway.
    Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB| | PubMed
  161. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
    Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM| | PubMed
  162. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.
    Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A| | PubMed
  163. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
    Kido Y, Matsson P, Giacomini KM| | PubMed
  164. Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.
    Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P| | PubMed
  165. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
    More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM| | PubMed
  166. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
    Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM| | PubMed
  167. Functional characterization of liver enhancers that regulate drug-associated transporters.
    Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N| | PubMed
  168. Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins.
    Minematsu T, Giacomini KM| | PubMed
  169. GABAA receptor open-state conformation determines non-competitive antagonist binding.
    Chen L, Xue L, Giacomini KM, Casida JE| | PubMed
  170. Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.
    Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM| | PubMed
  171. Consequences of POR mutations and polymorphisms.
    Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM| | PubMed
  172. Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.
    Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL| | PubMed
  173. Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.
    Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM| | PubMed
  174. SLC19A1 pharmacogenomics summary.
    Yee SW, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB| | PubMed
  175. Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.
    Agrawal V, Choi JH, Giacomini KM, Miller WL| | PubMed
  176. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.
    Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM| | PubMed
  177. Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.
    Chen L, Takizawa M, Chen E, Schlessinger A, Segenthelar J, Choi JH, Sali A, Kubo M, Nakamura S, Iwamoto Y, Iwasaki N, Giacomini KM| | PubMed
  178. Role of the copper transporter, CTR1, in platinum-induced ototoxicity.
    More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM| | PubMed
  179. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.
    Ahlin G, Chen L, Lazorova L, Chen Y, Ianculescu AG, Davis RL, Giacomini KM, Artursson P| | PubMed
  180. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.
    More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM| | PubMed
  181. Pharmacogenomics of membrane transporters: past, present and future.
    Yee SW, Chen L, Giacomini KM| | PubMed
  182. Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.
    Ianculescu AG, Friesema EC, Visser TJ, Giacomini KM, Scanlan TS| | PubMed
  183. Comparison of human solute carriers.
    Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A| | PubMed
  184. Membrane transporters in drug development.
    International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L| | PubMed
  185. The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA.
    Huang SM, Zhang L, Giacomini KM| | PubMed
  186. The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.
    Kroetz DL, Yee SW, Giacomini KM| | PubMed
  187. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    Treviño LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH, Evans WE, Relling MV| | PubMed
  188. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.
    Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P| | PubMed
  189. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
    Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM| | PubMed
  190. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy.
    Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM| | PubMed
  191. A survey of integral alpha-helical membrane proteins.
    Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A| | PubMed
  192. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.
    Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM| | PubMed
  193. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.
    Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM| | PubMed
  194. The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.
    McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM| | PubMed
  195. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.
    Chen Y, Teranishi K, Li S, Yee SW, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM| | PubMed
  196. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).
    Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM| | PubMed
  197. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).
    Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM| | PubMed
  198. Identification and characterization of 3-iodothyronamine intracellular transport.
    Ianculescu AG, Giacomini KM, Scanlan TS| | PubMed
  199. Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.
    Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, Miercke LJ, Giacomini KM, Sali A, Stroud RM| | PubMed
  200. Genetic variation in human P450 oxidoreductase.
    Miller WL, Huang N, Agrawal V, Giacomini KM| | PubMed
  201. Genetic variation in human aquaporins and effects on phenotypes of water homeostasis.
    Sorani MD, Manley GT, Giacomini KM| | PubMed
  202. Pharm. D. pathways to biomedical research: the National Institutes of Health special conference on pharmacy research.
    Figg WD, Chau CH, Okita R, Preusch P, Tracy TS, McLeod H, Reed M, Pieper J, Knoell D, Miller K, Speedie M, Blouin R, Kroboth P, Koda-Kimble MA, Taylor P, Cohen J, Giacomini K| | PubMed
  203. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
    Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM, Lippard SJ| | PubMed
  204. Creating and evaluating genetic tests predictive of drug response.
    Weiss ST, McLeod HL, Flockhart DA, Dolan ME, Benowitz NL, Johnson JA, Ratain MJ, Giacomini KM| | PubMed
  205. Genetic variation in drug transporters in ethnic populations.
    Cropp CD, Yee SW, Giacomini KM| | PubMed
  206. Novel variants in human Aquaporin-4 reduce cellular water permeability.
    Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT| | PubMed
  207. Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system.
    Sorani MD, Morabito D, Rosenthal G, Giacomini KM, Manley GT| | PubMed
  208. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
    Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL| | PubMed
  209. Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations.
    Huang N, Agrawal V, Giacomini KM, Miller WL| | PubMed
  210. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.
    Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM| | PubMed
  211. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.
    Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM| | PubMed
  212. Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4).
    Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM| | PubMed
  213. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
    Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM| | PubMed
  214. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.
    Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM| | PubMed
  215. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.
    Chen Y, Zhang S, Sorani M, Giacomini KM| | PubMed
  216. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
    Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM| | PubMed
  217. Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.
    Altman RB, Benowitz N, Gurwitz D, Lunshof J, Relling M, Lamba J, Wieben E, Mooney S, Giacomini K, Weiss S, Johnson JA, McLeod H, Flockhart D, Weinshilboum R, Shuldiner AR, Roden D, Krauss RM, Ratain M| | PubMed
  218. When good drugs go bad.
    Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y| | PubMed
  219. The pharmacogenetics research network: from SNP discovery to clinical drug response.
    Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I, Pharmacogenetics Research Network| | PubMed
  220. Pharmacogenomics: challenges and opportunities.
    Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST, Pharmacogenetics Research Network| | PubMed
  221. Organic cation transporters are determinants of oxaliplatin cytotoxicity.
    Zhang S, Lovejoy KS, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Chen Y, Komori T, Gray JW, Chen X, Lippard SJ, Giacomini KM| | PubMed
  222. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).
    Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM| | PubMed
  223. Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2.
    Owen RP, Badagnani I, Giacomini KM| | PubMed
  224. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.
    Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM| | PubMed
  225. PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.
    Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL| | PubMed
  226. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.
    Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM| | PubMed
  227. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.
    Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM| | PubMed
  228. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.
    Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM| | PubMed
  229. Functional genomics of membrane transporters in human populations.
    Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM| | PubMed
  230. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.
    Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM| | PubMed
  231. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.
    Owen RP, Lagpacan LL, Taylor TR, De La Cruz M, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM| | PubMed
  232. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
    Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM| | PubMed
  233. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.
    Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM| | PubMed
  234. Enhancing data sharing in collaborative research projects with DASH.
    Ferrin TE, Huang CC, Greenblatt DM, Stryke D, Giacomini KM, Morris JH| | PubMed
  235. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3).
    Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM| | PubMed
  236. Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease.
    Urban TJ, Giacomini KM, Risch N| | PubMed
  237. PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1.
    Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM| | PubMed
  238. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.
    Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM| | PubMed
  239. Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney.
    Mangravite LM, Badagnani I, Giacomini KM| | PubMed
  240. Estimating the contribution of genes and environment to variation in renal drug clearance.
    Leabman MK, Giacomini KM| | PubMed
  241. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
    Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG, Pharmacogenetics of Membrane Transporters Investigators| | PubMed
  242. PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2).
    Leabman MK, Huang CC, Stryke D, Johns SJ, Kawamoto M, Ferrin TE, DeYoung J, Taylor TR, De La Cruz M, Herskowitz I, Giacomini KM| | PubMed
  243. The concentrative nucleoside transporter family, SLC28.
    Gray JH, Owen RP, Giacomini KM| | PubMed
  244. Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1.
    Osato DH, Huang CC, Kawamoto M, Johns SJ, Stryke D, Wang J, Ferrin TE, Herskowitz I, Giacomini KM| | PubMed
  245. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
    Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM, Pharmacogenetics Of Membrane Transporters Investigators| | PubMed
  246. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
    Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM, Pharmacogenetics Of Membrane Transporters Investigators| | PubMed
  247. Sorting of rat SPNT in renal epithelium is independent of N-glycosylation.
    Mangravite LM, Giacomini KM| | PubMed
  248. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.
    Mangravite LM, Xiao G, Giacomini KM| | PubMed
  249. SNP analysis and presentation in the Pharmacogenetics of Membrane Transporters Project.
    Stryke D, Huang CC, Kawamoto M, Johns SJ, Carlson EJ, Deyoung JA, Leabman MK, Herskowitz I, Giacomini KM, Ferrin TE| | PubMed
  250. Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).
    Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM| | PubMed
  251. Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT.
    Gerstin KM, Dresser MJ, Giacomini KM| | PubMed
  252. Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition.
    Feng B, Shu Y, Giacomini KM| | PubMed
  253. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.
    Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM, Pharmacogenetics of Membrane Transporters Investigators| | PubMed
  254. Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells.
    Shu Y, Bello CL, Mangravite LM, Feng B, Giacomini KM| | PubMed
  255. Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.
    Feng B, Dresser MJ, Shu Y, Johns SJ, Giacomini KM| | PubMed
  256. Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line.
    Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM| | PubMed
  257. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes.
    Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB| | PubMed
  258. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters.
    Dresser MJ, Leabman MK, Giacomini KM| | PubMed
  259. A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans.
    Xiao G, Wang J, Tangen T, Giacomini KM| | PubMed
  260. Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes.
    Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM| | PubMed
  261. Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine.
    Gerstin KM, Dresser MJ, Wang J, Giacomini KM| | PubMed
  262. Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.
    Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM| | PubMed
  263. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1).
    Dresser MJ, Gray AT, Giacomini KM| | PubMed
  264. Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system.
    Schaner ME, Wang J, Zhang L, Su SF, Gerstin KM, Giacomini KM| | PubMed
  265. The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1.
    Zhang L, Gorset W, Dresser MJ, Giacomini KM| | PubMed
  266. Characterization of a bioengineered chimeric Na+-nucleoside transporter.
    Wang J, Giacomini KM| | PubMed
  267. Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter.
    Wang J, Giacomini KM| | PubMed
  268. Molecular and functional characteristics of cloned human organic cation transporters.
    Dresser MJ, Zhang L, Giacomini KM| | PubMed
  269. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
    Zhang L, Schaner ME, Giacomini KM| | PubMed
  270. Nucleoside transport in isolated human and rhesus choroid plexus tissue slices.
    Washington CB, Giacomini KM, Brett CM| | PubMed
  271. Nicotine transport in a human choriocarcinoma cell line (JAR).
    Zevin S, Schaner ME, Giacomini KM| | PubMed
  272. Molecular cloning and functional expression of a rabbit renal organic cation transporter.
    Terashita S, Dresser MJ, Zhang L, Gray AT, Yost SC, Giacomini KM| | PubMed
  273. Role of organic cation transporters in drug absorption and elimination.
    Zhang L, Brett CM, Giacomini KM| | PubMed
  274. Membrane transporters in drug disposition.
    Giacomini KM| | PubMed
  275. Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.
    Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM| | PubMed
  276. Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters.
    Wang J, Giacomini KM| | PubMed
  277. Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit.
    Ramanathan VK, Brett CM, Giacomini KM| | PubMed
  278. Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.
    Wang J, Schaner ME, Thomassen S, Su SF, Piquette-Miller M, Giacomini KM| | PubMed
  279. Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa).
    Schaner ME, Wang J, Zevin S, Gerstin KM, Giacomini KM| | PubMed
  280. Characterization of guanidine transport in human renal brush border membranes.
    Chun JK, Zhang L, Piquette-Miller M, Lau E, Tong LQ, Giacomini KM| | PubMed
  281. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
    Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM| | PubMed
  282. Cloning and functional expression of a human liver organic cation transporter.
    Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM| | PubMed
  283. Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes.
    Chun JK, Piquette-Miller M, Zhang L, Giacomini KM| | PubMed
  284. Guanidine transport in a human choriocarcinoma cell line (JAR).
    Zevin S, Schaner ME, Illsley NP, Giacomini KM| | PubMed
  285. Taurine transport in cultured choroid plexus.
    Ramanathan VK, Chung SJ, Giacomini KM, Brett CM| | PubMed
  286. Mechanisms of 5-fluorouracil (5-FU) transport in isolated rabbit choroid plexus tissue slices.
    Washington CB, Giacomini KM| | PubMed
  287. Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport.
    Ramanathan VK, Hui AC, Brett CM, Giacomini KM| | PubMed
  288. Saturable disposition of taurine in the rat cerebrospinal fluid.
    Chung SJ, Ramanathan VK, Brett CM, Giacomini KM| | PubMed
  289. Isolated renal brush border and basolateral membrane vesicles and cultured renal cells.
    Gutierrez MM, Brett CM, Giacomini KM| | PubMed
  290. Methods of study drug transport in isolated choroid plexus tissue and cultured cells.
    Washington CB, Giacomini KM, Brett CM| | PubMed
  291. Mechanisms of nucleobase transport in rabbit choroid plexus. Evidence for a Na(+)-dependent nucleobase transporter with broad substrate selectivity.
    Washington CB, Giacomini KM| | PubMed
  292. The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus.
    Washington CB, Brett CM, Wu X, Giacomini KM| | PubMed
  293. The effects of modulation of calcium influx through the voltage-sensitive calcium channel on cardiomyocyte hypertrophy.
    Lubic SP, Giacomini KM, Giacomini JC| | PubMed
  294. Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes.
    Gutierrez MM, Giacomini KM| | PubMed
  295. Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy.
    Lubic SP, Giacomini KM, Giacomini JC| | PubMed
  296. Expression of the choroid plexus sodium-nucleoside cotransporter (N3) in Xenopus laevis oocytes.
    Wu X, Giacomini KM| | PubMed
  297. Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus.
    Chung SJ, Ramanathan V, Giacomini KM, Brett CM| | PubMed
  298. Expression of a renal Na(+)-nucleoside cotransport system (N2) in Xenopus laevis oocytes.
    Giacomini KM, Markovich D, Werner A, Biber J, Wu X, Murer H| | PubMed
  299. Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit.
    Wu X, Gutierrez MM, Giacomini KM| | PubMed
  300. Effect of phenylisothiocyanate on organic cation transport in opossum kidney cells.
    Ott RJ, Chan JK, Ramanathan VK, Hui AC, Giacomini KM| | PubMed
  301. Stereoselective interactions of organic cations with the organic cation transporter in OK cells.
    Ott RJ, Giacomini KM| | PubMed
  302. Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney.
    Gutierrez MM, Giacomini KM| | PubMed
  303. Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine.
    Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM| | PubMed
  304. Formycin B elimination from the cerebrospinal fluid of the rat.
    Wu X, Hui AC, Giacomini KM| | PubMed
  305. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney.
    Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM| | PubMed
  306. Caring for the community
    Hayes K, Morgan B, Giacomini K, Dockal S.| | UCSF Research Profile
  307. Beta-adrenergic blockers as cardioprotective agents.
    Frishman WH| | PubMed
  308. Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction.
    Chang SW, Dutton D, Wang HL, He LS, Stearns R, Hui A, Giacomini KM, Ortiz de Montellano P, Voelkel NF| | PubMed
  309. Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides.
    Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM| | PubMed
  310. Nucleoside transport in brush border membrane vesicles from human kidney.
    Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM| | PubMed
  311. Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells.
    Ott RJ, Hui AC, Giacomini KM| | PubMed
  312. Organic cation transport in human renal brush-border membrane vesicles.
    Ott RJ, Hui AC, Yuan G, Giacomini KM| | PubMed
  313. Transport of organic cations by a renal epithelial cell line (OK).
    Yuan G, Ott RJ, Salgado C, Giacomini KM| | PubMed
  314. Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide.
    Lam YW, Boyd RA, Chin SK, Chang D, Giacomini KM| | PubMed
  315. Preparation of brush border membrane vesicles from bovine choroid plexus.
    Whittico MT, Hui AC, Giacomini KM| | PubMed
  316. Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles.
    Ott RJ, Hui AC, Wong FM, Hsyu PH, Giacomini KM| | PubMed
  317. Cimetidine transport in isolated brush border membrane vesicles from bovine choroid plexus.
    Whittico MT, Gang YA, Giacomini KM| | PubMed
  318. Mechanisms of interactions between organic anions and the organic cation transporter in renal brush border membrane vesicles.
    Ott RJ, Hai AC, Giacomini KM| | PubMed
  319. Computer-guided laser for neurosurgery.
    Koivukangas J, Louhisalmi Y| | PubMed
  320. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose.
    Boyd RA, Chin SK, Don-Pedro O, Verotta D, Sheiner LB, Williams RL, Giacomini KM| | PubMed
  321. High-performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. II. Studies with atenolol.
    Chin SK, Hui AC, Giacomini KM| | PubMed
  322. The effect of probenecid on the renal elimination of cimetidine.
    Gisclon LG, Boyd RA, Williams RL, Giacomini KM| | PubMed
  323. The pharmacokinetics of the enantiomers of atenolol.
    Boyd RA, Chin SK, Don-Pedro O, Williams RL, Giacomini KM| | PubMed
  324. Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium.
    Boyd RA, Giacomini JC, Giacomini KM| | PubMed
  325. Cimetidine elimination from the cerebrospinal fluid of the rat.
    Whittico MT, Giacomini KM| | PubMed
  326. Renal transport of drugs: an overview of methodology with application to cimetidine.
    Giacomini KM, Hsyu PH, Gisclon LG| | PubMed
  327. Stereoselective binding of disopyramide to plasma proteins.
    Valdivieso L, Giacomini KM, Nelson WL, Pershe R, Blaschke TF| | PubMed
  328. The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles.
    Hsyu PH, Wong FM, Giacomini KM| | PubMed
  329. Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney.
    Gisclon LG, Giacomini KM| | PubMed
  330. Interactions of organic anions with the organic cation transporter in renal BBMV.
    Hsyu PH, Gisclon LG, Hui AC, Giacomini KM| | PubMed
  331. Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium.
    Boyd RA, Giacomini JC, Wong FM, Nelson WL, Giacomini KM| | PubMed
  332. Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney.
    Gisclon L, Wong FM, Giacomini KM| | PubMed
  333. Essential tyrosine residues in transport of organic cations in renal BBMV.
    Hsyu PH, Giacomini KM| | PubMed
  334. The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange.
    Hsyu PH, Giacomini KM| | PubMed
  335. Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil.
    Theodore LJ, Nelson WL, Zobrist RH, Giacomini KM, Giacomini JC| | PubMed
  336. The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.
    Zobrist RH, Giacomini KM, Nelson WL, Giacomini JC| | PubMed
  337. In vivo interaction of the enantiomers of disopyramide in human subjects.
    Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, Blaschke TF| | PubMed
  338. Posttraumatic complications and inflammatory mediators.
    Nuytinck JK, Goris JA, Redl H, Schlag G, van Munster PJ| | PubMed
  339. High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol.
    Hsyu PH, Giacomini KM| | PubMed
  340. Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel.
    Giacomini JC, Nelson WL, Wong FM, Boyd R, Zobrist RH, Giacomini KM| | PubMed
  341. Stereoselective renal clearance of pindolol in humans.
    Hsyu PH, Giacomini KM| | PubMed
  342. Electrophysiology of the enantiomers of disopyramide in dogs.
    Giacomini JC, Giacomini KM, Nelson WL, Harrison DC, Blaschke TF| | PubMed
  343. The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits.
    Giacomini JC, Nelson WL, Theodore L, Wong FM, Rood D, Giacomini KM| | PubMed
  344. Verapamil interacts stereoselectively with the muscarinic receptor.
    Giacomini JC, Zobrist RH, Dave B, Giacomini KM| | PubMed
  345. Decreased binding of verapamil to plasma proteins in patients with liver disease.
    Giacomini KM, Massoud N, Wong FM, Giacomini JC| | PubMed
  346. Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration.
    Giacomini KM, Wong FM, Tozer TN| | PubMed
  347. High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma.
    Smith GA, Giacomini KM, Smith CT, Gregory PB, Robinson WS, Merigan TC, Blaschke TF| | PubMed
  348. Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide.
    Giacomini KM, Blaschke TF| | PubMed
  349. Amitriptyline disposition in young and elderly normal men.
    Schulz P, Turner-Tamiyasu K, Smith G, Giacomini KM, Blaschke TF| | PubMed
  350. Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin.
    Schulz P, Abang A, Giacomini JC, Blaschke TF, Giacomini KM| | PubMed
  351. Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man.
    Schulz P, Giacomini KM, Luttrell S, Turner-Tamiyasu K, Blaschke TF| | PubMed
  352. Calculation of drug concentration in plasma after equilibrium dialysis.
    Giacomini KM, Abang A, Blaschke TF| | PubMed
  353. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study.
    Pollick C, Giacomini KM, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL| | PubMed
  354. High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood.
    Smith GA, Schulz P, Giacomini KM, Blaschke TF| | PubMed
  355. Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography.
    Swezey SF, Giacomini KM, Abang A, Brass C, Stevens DA, Blaschke TF| | PubMed
  356. The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide.
    Giacomini KM, Swezey SE, Turner-Tamiyasu K, Blaschke TF| | PubMed
  357. Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.
    Nelson WL, Sneed CK, Giacomini KM, Giacomini JC, Stauss J, Blaschke TF, Cox BM| | PubMed
  358. Evaluation of methods for producing renal dysfunction in rats.
    Giacomini KM, Roberts SM, Levy G| | PubMed
  359. Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins.
    Giacomini KM, Giacomini JC, Blaschke TF| | PubMed
  360. The stereoselective disposition of disopyramide in the dog.
    Giacomini KM, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF| | PubMed
  361. Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum.
    Giacomini KM, Cox BM, Blaschke TF| | PubMed
  362. Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma.
    Giacomini KM, Swezey SE, Giacomini JC, Blaschke TF| | PubMed
  363. Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt.
    Giacomini KM, Giacomini JC, Gibson TP, Levy G| | PubMed
  364. Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs.
    Giacomini KM, Nakeeb SM, Levy G| | PubMed
  365. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient.
    Gibson TP, Giacomini KM, Briggs WA, Whitman W, Levy G| | PubMed
  366. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients.
    Giacomini KM, Gibson TP, Levy G| | PubMed
  367. Phenylalanine metabolism in uremic and normal man.
    Jones MR, Kopple JD, Swendseid ME| | PubMed
  368. Rational aspirin dosage regimens.
    Levy G, Giacomini KM| | PubMed
  369. Plasma protein binding of d-propoxyphene in normal subjects and anephric patients.
    Giacomini KM, Gibson TP, Levy G| | PubMed
  370. A Convenient Method for Repetitive Blood Sampling in the Dog
    Soles C, Giacomini KM, Roberts SM, Giacomini JC. Soles C, Giacomini KM, Roberts SM, Giacomini JC.| | UCSF Research Profile
  371. [Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease].
    Senet JM, Robert R, Mauras G| | PubMed