University of California San Francisco

Jeroen Roose, PhD
Jeroen Roose, PhD

Professor and Vice-chair, Anatomy

Address

513 Parnassus Avenue, HSW, #1325
San Francisco, CA 94143
United States

Email: [email protected]
Phone: 415-476-3977
Fax: 415-476-4845

ORCID: 0000-0003-4746-2811

Education

Institution Degree Dept or School End Date
University of California, San Francisco Postdoctoral Studies Graduate Division
University of Utrecht PhD Immunology

Awards & Honors

Award Conferred By Date
Endeavor (Co-Lead) Mark Foundation for Cancer Research 2021/2025
R01 (Roose) NCI 2015/2026
MPI R01 (Lead) NHLBI 2015/2020
Innovator Award Alex Lemonade Stand Foundation 2015/2017
R01 (Roose) NIAID 2014/2019
2013 Outstanding Faculty Mentor Award UCSF PSA (Postdoctoral Scholar’s Association) 2013/2013
Research Aaward Gabrielle's Angel Foundatoin 2012/2014
P01 (Co-Lead/Lead) NIAID 2011/2027
PhD award summa cum laude University of Utrecht, The Netherlands 1999/1999

Grants and Funding

  • Roles for Intracellular pH dynamics in cancer | NIH/NCI | 2023-04-01 - 2028-03-31 | Role: PI
  • Defining the unique properties of the distinct signaling machinery used by the TCR | NIH/NIAID | 2022-05-01 - 2027-04-30 | Role: Co-Lead/PI
  • Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence | NIH/NCI | 2022-01-01 - 2026-12-30 | Role: PI
  • Defining and re-engineering the DTC and metastatic cell surface to prevent lethal breast cancer metastasis | DoD | 2022-08-01 - 2026-07-30 | Role: PI
  • Understand and Eliminate Metastatic Cancer | Mark Foundation for Cancer Research | 2020-12-01 - 2023-11-30 | Role: Co-Lead/PI
  • Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants | NIH | 2014-03-01 - 2022-05-31 | Role: Principal Investigator
  • Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR | NIH | 2011-07-15 - 2021-06-30 | Role: Co-Investigator
  • Balanced signaling cues to guide cell transitions in the blood lineage continuum | NIH | 2015-08-15 - 2021-04-30 | Role: Principal Investigator
  • Molecular understanding of cytokine-Ras signals in leukemic bone marrow | NIH | 2015-07-01 - 2020-06-30 | Role: Principal Investigator
  • Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants | NIH | 2014-03-01 - 2019-02-28 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 100
  1. STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.
    Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A| | PubMed
  2. Abstract 3837: PI-3 kinase acts upstream of oncogenic Ras in hematopoietic cells through a cytokine-PLC?-RasGRP pathway.
    Ernesto Diaz-Flores, Hana Goldschmidt, Philippe Depeille, Victor Ng, Jeroen Roose, Kevan Shokat, Benjamin Braun, Kevin Shannon| | UCSF Research Profile
  3. PI3 Kinase, Phospholipase C (PLC)-?, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.
    Ernesto Diaz-Flores, Hana Leah Goldschmidt, Philippe Depeille, Victor Ng, Jeroen Roose, Kevan Shokat, Benjamin S. Braun, Kevin Shannon| | UCSF Research Profile
  4. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
    Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K| | PubMed
  5. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.
    Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J| | PubMed
  6. Digital signaling and hysteresis characterize ras activation in lymphoid cells.
    Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP| | PubMed
  7. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.
    Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK| | PubMed
  8. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.
    Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A| | PubMed
  9. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
    Nirula A, Ho M, Phee H, Roose J, Weiss A| | PubMed
  10. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
    Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A| | PubMed
100
View all 100 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 100
  1. nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
    Hendley AM, Ashe S, Urano A, Ng M, Phu TA, Peng XL, Luan C, Finger AM, Jang GH, Kerper NR, Berrios DI, Jin D, Lee J, Riahi IR, Gbenedio OM, Chung C, Roose JP, Yeh JJ, Gallinger S, Biankin AV, O'Kane GM, Ntranos V, Chang DK, Dawson DW, Kim GE, Weaver VM, Raffai RL, Hebrok M| | PubMed
  2. Abstract A066: nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
    Audrey M Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan A Phu, Xianlu Laura Peng, Changfei Luan, Anna-Marie Finger, Gun Ho Jang, Natanya R Kerper, David I Berrios, David Jin, Jonghyun Lee, Irene R Riahi, Oghenekevwe M Gbenedio, Christina Chung, Jeroen P Roose, Jen Jen Yeh, Steven Gallinger, Andrew V Biankin, Grainne M O’Kane, Vasilis Ntranos, David K Chang, David W Dawson, Grace E Kim, Valerie M Weaver, Robert L Raffai, Matthias Hebrok| | UCSF Research Profile
  3. Immediate myeloid depot for SARS-CoV-2 in the human lung.
    Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR| | PubMed
  4. NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
    Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M| | PubMed
  5. Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer.
    Haderk F, Chou YT, Cech L, Fernández-Méndez C, Yu J, Olivas V, Meraz IM, Barbosa Rabago D, Kerr DL, Gomez C, Allegakoen DV, Guan J, Shah KN, Herrington KA, Gbenedio OM, Nanjo S, Majidi M, Tamaki W, Pourmoghadam YK, Rotow JK, McCoach CE, Riess JW, Gutkind JS, Tang TT, Post L, Huang B, Santisteban P, Goodarzi H, Bandyopadhyay S, Kuo CJ, Roose JP, Wu W, Blakely CM, Roth JA, Bivona TG| | PubMed
  6. Abstract 7465: Leukemia inhibitory factor creates an immune suppressive tumor microenvironment and fosters tumor growth in KRAS-driven pancreatic ductal adenocarcinoma.
    Lisa Miller-Phillips, Imene Boukhalfa Hanafi, Alexis J. Combes, Shabana Bano, Lisiena Hysenaj, Jeroen P. Roose, Adam Olshen, Ashley Kiemen, Sarah Umetsu, Man-Tzu Wang, Eric A. Collisson| | UCSF Research Profile
  7. Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma.
    Audrey M. Hendley, Atsushi Urano, Xianlu L. Peng, Sudipta Ashe, Tuan A. Phu, Martin Ng, Natanya R. Kerper, David I. Berrios, Jonghyun Lee, David Jin, Gun H. Jang, Oghenekevwe M. Gbenedio, Jeroen P. Roose, Jen J. Yeh, Steven Gallinger, Andrew V. Biankin, Vasilis Ntranos, David K. Chang, David W. Dawson, Grace E. Kim, Valerie M. Weaver, Robert L. Raffai, Matthias Hebrok| | UCSF Research Profile
  8. Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.
    Karra L, Finger AM, Shechtman L, Krush M, Huang RM, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP| | PubMed
  9. Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.
    Chang Y, Manivannan P, Doosti A, Lapinski PE, Chen D, Roose JP, King PD| | PubMed
  10. Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression.
    Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC| | PubMed
  11. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
    Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP| | PubMed
  12. Abstract IA022: Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment.
    Hugo Gonzalez, Wenbin Mei, Isabella Robles, Catharina Hagerling, Breanna Allen, Trine Hauge Okholm, Ankitha Nanjaraj, Tamara Verbeek, Sandhya Kalavacherla, Merel van Gogh, Stephen Georgiou, Mariza Daras, Joanna J. Phillips, Matthew H. Spitzer, Jeroen P. Roose, Zena Werb| | UCSF Research Profile
  13. NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
    Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M| | PubMed
  14. Immediate myeloid depot for SARS-CoV-2 in the human lung.
    Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR| | PubMed
  15. Immediate myeloid depot for SARS-CoV-2 in the human lung.
    Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR| | PubMed
  16. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice.
    Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J| | PubMed
  17. Cellular architecture of human brain metastases.
    Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z| | PubMed
  18. Editorial overview: Communities in immune cell signaling.
    Roose J, Barton G| | PubMed
  19. 603 Autoreactivity drives increased metabolism in T cells from SLE patients?.
    Kriti Bahl, Darienne Myers, Jeroen Roose| | UCSF Research Profile
  20. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
    Wen Z, Yun G, Hebert A, Kong G, Ranheim EA, Finn R, Rajagoplan A, Li S, Zhou Y, Yu M, Damnernsawad A, Roose JP, Coon JJ, Wen R, Wang D, Zhang J| | PubMed
  21. SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
    Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP| | PubMed
  22. T cells: a dedicated effector kinase pathways for every trait?
    Bahl K, Roose JP| | PubMed
  23. Investigating increased hematopoietic stem cell fitness in a novel mouse model.
    Karra L, Roose JP| | PubMed
  24. Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models.
    Li PJ, Roose JP, Jablons DM, Kratz JR| | PubMed
  25. Regulation of the Small GTPase Ras and Its Relevance to Human Disease.
    Kulhanek KR, Roose JP, Rubio I| | PubMed
  26. Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.
    Baars MJD, Douma T, Simeonov DR, Myers DR, Kulhanek K, Banerjee S, Zwakenberg S, Baltissen MP, Amini M, de Roock S, van Wijk F, Vermeulen M, Marson A, Roose JP, Vercoulen Y| | PubMed
  27. Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
    Karra L, Romero-Moya D, Ksionda O, Krush M, Gu Z, Mues M, Depeille P, Mullighan C, Roose JP| | PubMed
  28. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
    Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC| | PubMed
  29. Protocol for Barcoding T Cells Combined with Timed Stimulations.
    Kulhanek KR, Myers DR, Ksionda O, Vercoulen Y, Romero-Moya D, Roose JP| | PubMed
  30. Protocol for Comprehensive Synthetic Lethality Screens.
    Romero-Moya D, Roose JP| | PubMed
  31. Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer.
    Samocha A, Doh H, Kessenbrock K, Roose JP| | PubMed
  32. Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.
    Kondo Y, Ognjenovic J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J| | PubMed
  33. mTOR and other effector kinase signals that impact T cell function and activity.
    Myers DR, Wheeler B, Roose JP| | PubMed
  34. Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
    Jun JE, Kulhanek KR, Chen H, Chakraborty A, Roose JP| | PubMed
  35. RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
    Gbenedio OM, Bonnans C, Grun D, Wang CY, Hatch AJ, Mahoney MR, Barras D, Matli M, Miao Y, Garcia KC, Tejpar S, Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P| | PubMed
  36. Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.
    Myers DR, Norlin E, Vercoulen Y, Roose JP| | PubMed
  37. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
    Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP| | PubMed
  38. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.
    Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP| | PubMed
  39. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.
    Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP| | PubMed
  40. Tonic Signals: Why Do Lymphocytes Bother?
    Myers DR, Zikherman J, Roose JP| | PubMed
  41. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
    Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP| | PubMed
  42. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.
    Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC| | PubMed
  43. Lost GRP on cytotoxicity?
    Roose JP| | PubMed
  44. One-way membrane trafficking of SOS in receptor-triggered Ras activation.
    Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT| | PubMed
  45. Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle.
    Mues M, Roose JP| | PubMed
  46. Abstract B22: Screening and validation of combination therapy in T cell leukemia.
    Marsilius Mues, Marthe F. Lindenbergh, Michael T. McManus, Jeroen P. Roose| | UCSF Research Profile
  47. Suppressive signals in colorectal cancer: RasGRP1 a new marker for anti-EGFR therapy?.
    Jeroen Roose, Philippe Depeille, Robert S. Warren| | UCSF Research Profile
  48. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.
    Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM| | PubMed
  49. Kinase and Phosphatase Effector Pathways in T Cells.
    Darienne R. Myers, Jeroen P. Roose| | UCSF Research Profile
  50. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.
    Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP| | PubMed
  51. Unexpected insights for anti-EGFR cancer therapy.
    Depeille P, Warren RS, Roose JP| | PubMed
  52. Abstract 2138: RasGRP3 mediates MAPK pathway activation in GNAQ mutant uveal melanoma.
    Xu Chen, Qiuxia Wu, Philippe Depeille, Jeroen P. Roose, Boris C. Bastian| | UCSF Research Profile
  53. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
    Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP| | PubMed
  54. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
    Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD| | PubMed
  55. Editorial overview: lymphocyte development and activation: lymphocytes, integrators of information.
    Roose J, Fagarasan S| | PubMed
  56. Flavors of EGFR-Ras signals impacting intestinal homeostasis.
    Depeille P, Roose JP| | PubMed
  57. Abstract LB-306: The Ras exchange factor RasGRP1 opposes proliferative EGFR-SOS1 Ras signals and restricts intestinal epithelial cell growth.
    Philippe Depeille, Linda M. Henricks, Robert van de Ven, Ed Lemmens, Mary Matli, Kevin M. Haigis, David Donner, Robert Warren, Jeroen P. Roose| | UCSF Research Profile
  58. Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.
    Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP| | PubMed
  59. Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.
    Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP| | PubMed
  60. PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras.
    Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K| | PubMed
  61. RasGRP Ras guanine nucleotide exchange factors in cancer.
    Ksionda O, Limnander A, Roose JP| | PubMed
  62. Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.
    Jun JE, Rubio I, Roose JP| | PubMed
  63. Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
    Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J| | PubMed
  64. Biochemical heterogeneity and developmental varieties in T-cell leukemia.
    Chakraborty AK, Roose JP| | PubMed
  65. Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.
    Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP| | PubMed
  66. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
    Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP| | PubMed
  67. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
    Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL| | PubMed
  68. The membrane environment can promote or suppress bistability in cell signaling networks.
    Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK| | PubMed
  69. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
    Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP| | PubMed
  70. Stim1, PKCd and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development (109.6).
    Andre Limnander, Philippe Depeille, Tanya Freedman, Jen Liou, Michael Leitges, Tomohiro Kurosaki, Jeroen Roose, Arthur Weiss| | UCSF Research Profile
  71. STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.
    Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A| | PubMed
  72. Abstract 3837: PI-3 kinase acts upstream of oncogenic Ras in hematopoietic cells through a cytokine-PLC?-RasGRP pathway.
    Ernesto Diaz-Flores, Hana Goldschmidt, Philippe Depeille, Victor Ng, Jeroen Roose, Kevan Shokat, Benjamin Braun, Kevin Shannon| | UCSF Research Profile
  73. PI3 Kinase, Phospholipase C (PLC)-?, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.
    Ernesto Diaz-Flores, Hana Leah Goldschmidt, Philippe Depeille, Victor Ng, Jeroen Roose, Kevan Shokat, Benjamin S. Braun, Kevin Shannon| | UCSF Research Profile
  74. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
    Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K| | PubMed
  75. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.
    Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J| | PubMed
  76. Digital signaling and hysteresis characterize ras activation in lymphoid cells.
    Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP| | PubMed
  77. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.
    Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK| | PubMed
  78. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.
    Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A| | PubMed
  79. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
    Nirula A, Ho M, Phee H, Roose J, Weiss A| | PubMed
  80. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
    Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A| | PubMed
  81. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.
    Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A| | PubMed
  82. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
    Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A| | PubMed
  83. All Tcf HMG box transcription factors interact with Groucho-related co-repressors.
    Brantjes H, Roose J, van De Wetering M, Clevers H| | PubMed
  84. T cells: getting a GRP on Ras.
    Roose J, Weiss A| | PubMed
  85. dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila.
    Lawrence N, Dearden P, Hartley D, Roose J, Clevers H, Arias AM| | PubMed
  86. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis.
    Molenaar M, Brian E, Roose J, Clevers H, Destrée O| | PubMed
  87. TCF transcription factors: molecular switches in carcinogenesis.
    Roose J, Clevers H| | PubMed
  88. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
    Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H| | PubMed
  89. The Sox-13 gene: structure, promoter characterization, and chromosomal localization.
    Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H| | PubMed
  90. Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
    Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M, Bejsovec A| | PubMed
  91. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.
    Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, van de Wetering M, Destrée O, Clevers H| | PubMed
  92. Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development.
    Molenaar M, Roose J, Peterson J, Venanzi S, Clevers H, Destrée O| | PubMed
  93. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.
    Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H| | PubMed
  94. High expression of the HMG box factor sox-13 in arterial walls during embryonic development.
    Roose J, Korver W, Oving E, Wilson A, Wagenaar G, Markman M, Lamers W, Clevers H| | PubMed
  95. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization.
    Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H| | PubMed
  96. The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.
    Korver W, Roose J, Wilson A, Clevers H| | PubMed
  97. The winged-helix transcription factor Trident is expressed in cycling cells.
    Korver W, Roose J, Clevers H| | PubMed
  98. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.
    Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destrée O, Clevers H| | PubMed
  99. Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva.
    Toye PG, Metzelaar MJ, Wijngaard PL, Nene V, Iams K, Roose J, Nyanjui JK, Gobright E, Musoke AJ, Clevers HC| | PubMed
  100. Synthetic protease inhibitors: promising compounds to arrest pathobiologic processes.
    Roose JP, Van Noorden CJ| | PubMed