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Julie Saba, MD, PhD

Julie Saba, MD, PhD

  • Professor, Pediatrics

Contact Information

35 Medical Center Way
San Francisco, CA 94143
julie.saba@ucsf.edu
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  Institution  
  Degree    
  Dept or School    
  End Date    
  • University of California, San Francisco
  • Diversity, Equity, and Inclusion Champion Training
  • 10/2020
  • Duke University, Durham, NC
  • Ph.D.
  • Biochemistry/Cell Biology
  • 05/1996
  • Duke University Medical Center, Durham, NC
  • Pediatric Fellowship
  • Hematology/Oncology
  • 07/1993
  • Duke University Medical Center, Durham, NC
  • Residency
  • Pediatrics
  • 07/1989
  • Johns Hopkins University, Baltimore, MD
  • M.A.
  • Creative Writing
  • 05/1986
  • University of Maryland School of Medicine, Baltimore, MD
  • M.D.
  • Medicine
  • 05/1985
  • Johns Hopkins University, Baltimore, MD
  • B.S.
  • Natural Sciences
  • 05/1981
  • physician-scientist
    (she/her/hers)

    Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays important roles in development, vascular biology, immune cell trafficking, carcinogenesis and other physiological processes. S1P mediates its actions primarily by signaling through a family of G protein-coupled receptors. Our research group is investigating the role of S1P metabolism and signaling in development and disease using cellular and animal models, translational approaches and metabolomics profiling. Our recent findings demonstrate that defects in S1P metabolism underlie a novel childhood syndrome called sphingosine phosphate lyase insufficiency syndrome (SPLIS), which is characterized by defects of kidney, adrenal gland, neurological system, skin and immune system. We are now developing several therapeutic approaches to the treatment of SPLIS including gene therapy and cofactor supplementation.
      Award  
      Confired By    
      Date    
  • Director, Swim Across America National Laboratory
  • Children's Hospital and Research Center Oakland
  • 2015
  • John and Edna Beck Chair in Pediatric Cancer Research
  • Children's Hospital and Research Center Oakland
  • 2012
  • Data provided by UCSF Profiles, powered by CTSI
    • Providing a cure for sphingosine phosphate lyase insufficiency syndrome (SPLIS) through adeno-associated viral mediated SGPL1 gene therapy
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      Apr 2022
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      Mar 2024
      Principal Investigator
    • SPLIS Patient Finding
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      Feb 2022
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      Feb 2023
      Principal Investigator
    • Endogenous and Dietary Sphingolipids as Modulators in Inflammatory Bowel Disease
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      Jun 2018
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      May 2022
      Principal Investigator
    • S1P Lyase in colon cancer
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      Jul 2007
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      Jan 2018
      Principal Investigator
    • Agilent 6490 Triple Quadrupole Mass Spectrometer
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      Jun 2014
      -
      May 2015
      Principal Investigator
    • Sphingolipid Metabolism in Drosophila Development
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      Sep 2003
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      Feb 2015
      Principal Investigator
    • IVIS Spectrum small animal imaging system
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      Jun 2013
      -
      Jun 2014
      Principal Investigator
    • FASEB SRC on Lysophospholipd Mediators in Health and Disease
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      Aug 2011
      -
      Aug 2012
      Principal Investigator
    • Soy sphingadienes and related compounds in colon cancer chemoprevention and treat
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      Sep 2009
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      Jul 2012
      Principal Investigator
    • Endogenous sphingosine-1-phosphate as a radioprotector of intestinal tissues
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      Sep 2007
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      Feb 2011
      Principal Investigator
    • Sphingosine Phosphate:Regulation and Role in Cancer
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      Sep 1998
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      Feb 2011
      Principal Investigator
    • CERAMIDE MEDIATED SIGNAL TRANSDUCTION IN YEAST
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      Jul 1993
      -
      Jun 1998
      Principal Investigator
    Data provided by UCSF Profiles, powered by CTSI
    MOST RECENT PUBLICATIONS FROM A TOTAL OF 117
    Data provided by UCSF Profiles, powered by CTSI
    1. De la Garza-Rodea AS, Moore SA, Zamora-Pineda J, Hoffman EP, Mistry K, Kumar A, Strober JB, Zhao P, Suh JH, Saba JD. Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice. Int J Mol Sci. 2022 Jul 08; 23(14). View in PubMed
    2. Wolf JJ, Saba JD, Hahm B. Analyzing Opposing Interactions Between Sphingosine 1-Phosphate Lyase and Influenza A Virus. DNA Cell Biol. 2022 Apr; 41(4):331-335. View in PubMed
    3. Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Int J Mol Sci. 2021 Sep 30; 22(19). View in PubMed
    4. Saba JD, Keller N, Wang JY, Tang F, Slavin A, Shen Y. Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome. Cell Biochem Biophys. 2021 Sep; 79(3):547-559. View in PubMed
    5. Zhao P, Tassew GB, Lee JY, Oskouian B, Muñoz DP, Hodgin JB, Watson GL, Tang F, Wang JY, Luo J, Yang Y, King S, Krauss RM, Keller N, Saba JD. Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome. JCI Insight. 2021 04 22; 6(8). View in PubMed
    6. View All Publications

     

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