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Jeroen Roose, PhD

Jeroen Roose, PhD

  • Professor and Vice-chair, Anatomy

Contact Information

513 Parnassus Ave, HSW
San Francisco, CA 94143
Phone: 415-476-3977
Fax: 415-476-4845
jeroen.roose@ucsf.edu
Orchid: Orchid 0000-0003-4746-2811
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  Institution  
  Degree    
  Dept or School    
  End Date    
  • University of California, San Francisco
  • Postdoctoral Studies
  • Graduate Division
  • University of Utrecht
  • PhD
  • Immunology
  • Research Interests:

    Our laboratory is interested in genetic lesions that lead to abnormal Ras signal transduction events and development of diseases such as autoimmunity and cancer. Active Ras communicates to many downstream targets and affects many cell biological responses. Our goal is to understand the mechanism of activation of the small GTPase Ras by Ras exchange factors and its role in normal physiology as well as understand how alterations in Ras-kinase signals underlie pathology. http://rooselab.ucsf.edu/
      Award  
      Confired By    
      Date    
  • Innovator Award
  • Alex Lemonade Stand Foundation
  • 2015 - 2017
  • 2013 Outstanding Faculty Mentor Award
  • UCSF PSA (Postdoctoral Scholar’s Association)
  • 2013 - 2013
  • Junior Investigator
  • Gabrielle's Angel Foundation
  • 2012 - 2015
  • Kimmel Scholar Award
  • Sydney Kimmel Foundation
  • 2008 - 2010
  • K01 Howard Temin career development Award
  • NIH - NCI
  • 2006 - 2011
  • Arthritis Investigator Award
  • Arthritis Foundation
  • 2006 - 2010
  • Postdoctoral Award
  • Dutch Cancer Society KWF
  • 2000 - 2003
  • Postdoctoral Award TALENT
  • Dutch Sientific Organization NWO
  • 1999 - 2000
  • PhD award summa cum laude
  • University of Utrecht, The Netherlands
  • 1999 - 1999
  • Data provided by UCSF Profiles, powered by CTSI
    ORCID iD: 0000-0003-4746-2811 Additional info
    • Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants
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      Mar 2014
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      May 2022
      Principal Investigator
    • Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR
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      Jul 2011
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      Jun 2021
      Co-Investigator
    • Balanced signaling cues to guide cell transitions in the blood lineage continuum
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      Aug 2015
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      Apr 2021
      Principal Investigator
    • Molecular understanding of cytokine-Ras signals in leukemic bone marrow
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      Jul 2015
      -
      Jun 2020
      Principal Investigator
    • Bio-Organic Biomedical Mass Spectrometry Resource
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      Mar 1982
      -
      May 2015
      Co-Investigator
    • Mechanistic Studies of Ras-MAPK Signals: Specialzed Cues for the T cell Lineage?
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      Sep 2011
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      Aug 2012
      Principal Investigator
    • The role of tonic signal-input in stable gene profiles
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      Aug 2006
      -
      Jul 2011
      Principal Investigator
    MOST RECENT PUBLICATIONS FROM A TOTAL OF 82
    Data provided by UCSF Profiles, powered by CTSI
    1. Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17. View in PubMed
    2. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11. View in PubMed
    3. Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice. Leukemia. 2022 04; 36(4):1167-1170. View in PubMed
    4. Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z. Cellular architecture of human brain metastases. Cell. 2022 02 17; 185(4):729-745.e20. View in PubMed
    5. Roose J, Barton G. Editorial overview: Communities in immune cell signaling. Curr Opin Immunol. 2021 12; 73:iii-iv. View in PubMed
    6. View All Publications

     

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