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Jeroen Roose, PhD

Jeroen Roose, PhD

  • Professor and Vice-chair, Anatomy

Contact Information

513 Parnassus Ave, HSW, #1325
San Francisco, CA 94143
Phone: 415-476-3977
Fax: 415-476-4845
[email protected]
Orchid: Orchid 0000-0003-4746-2811
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Education

  Institution  
  Degree    
  Dept or School    
  End Date    
  • University of California, San Francisco
  • Postdoctoral Studies
  • Graduate Division
  • University of Utrecht
  • PhD
  • Immunology

  • Biography

    Research Interests:

    Our laboratory focuses on understanding cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of immunology, cancer, and stem cell biology. We have a very international team that embraces DEI. Post docs in my lab go off to start their own academic labs or secure exciting positions in industry. http://rooselab.ucsf.edu/

    In addition to running our lab, I enjoy setting up large collaborative research programs so that my team members (and everyone else) can benefit. In 2018, I co-founded ImmunoX. Also in 2018, I started an Organoid disease to biology (D2B) unit. I co-lead the UCSF Endeavor Program that focuses on cancer metastasis and co-lead the UCSF AutoImmunoProfiler Initiative.

    Awards & Honors

      Award  
      Confired By    
      Date    
  • Innovator Award
  • Alex Lemonade Stand Foundation
  • 2015 - 2017
  • 2013 Outstanding Faculty Mentor Award
  • UCSF PSA (Postdoctoral Scholar’s Association)
  • 2013 - 2013
  • Junior Investigator
  • Gabrielle's Angel Foundation
  • 2012 - 2015
  • Kimmel Scholar Award
  • Sydney Kimmel Foundation
  • 2008 - 2010
  • K01 Howard Temin career development Award
  • NIH - NCI
  • 2006 - 2011
  • Arthritis Investigator Award
  • Arthritis Foundation
  • 2006 - 2010
  • Postdoctoral Award
  • Dutch Cancer Society KWF
  • 2000 - 2003
  • Postdoctoral Award TALENT
  • Dutch Sientific Organization NWO
  • 1999 - 2000
  • PhD award summa cum laude
  • University of Utrecht, The Netherlands
  • 1999 - 1999

    • Mentoring Overview

    Dr. Roose's research focuses on the impact Ras kinase signals have on cell fate decisions in health and disease, spanning the continuum from basic science to pre-clinical investigations. Dr. Roose also runs an organoid disease to biology unit connected to UCSF's CoLabs offering a rich training environment for staff, students, postdocs, and fellows cellular and translational biology and associated methods. Dr. Roose takes on several leadership positions in the UCSF graduate schools and has trained many graduate students and postdoc who have gone on to successful academic and biotech positions. In 2013 he received the 9th annual Mentoring award by the UCSF Postdoctoral Scholar's Association.

    Training opportunities in Dr. Roose's lab and his Organoid D2B unit include studies on cellular signaling and cell fate choices, therapy, and biomarker discovery using organoids from UCSF cancer patients in a collaborative team setting.

    Research & Funding

    Data provided by UCSF Profiles, powered by CTSI
    ORCID iD: 0000-0003-4746-2811 Additional info
    • Roles for Intracellular pH dynamics in cancer
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      Apr 2023
      -
      Mar 2028
      PI
    • Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence
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      Jan 2022
      -
      Dec 2026
      PI
    • Defining and re-engineering the DTC and metastatic cell surface to prevent lethal breast cancer metastasis
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      Funding Period:
      Aug 2022
      -
      Jul 2026
      PI
    • Understand and Eliminate Metastatic Cancer
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      Funding Period:
      Dec 2020
      -
      Nov 2023
      Co-Lead/PI
    • Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants
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      Funding Period:
      Mar 2014
      -
      May 2022
      Principal Investigator
    • Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR
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      Jul 2011
      -
      Jun 2021
      Co-Investigator
    • Balanced signaling cues to guide cell transitions in the blood lineage continuum
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      Aug 2015
      -
      Apr 2021
      Principal Investigator
    • Molecular understanding of cytokine-Ras signals in leukemic bone marrow
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      Jul 2015
      -
      Jun 2020
      Principal Investigator
    • Bio-Organic Biomedical Mass Spectrometry Resource
      Sponsor:
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      Mar 1982
      -
      May 2015
      Co-Investigator
    • Mechanistic Studies of Ras-MAPK Signals: Specialzed Cues for the T cell Lineage?
      Sponsor:
      Sponsor ID:
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      Sep 2011
      -
      Aug 2012
      Principal Investigator
    • The role of tonic signal-input in stable gene profiles
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      Aug 2006
      -
      Jul 2011
      Principal Investigator

    Publications

    MOST RECENT PUBLICATIONS FROM A TOTAL OF 90
    Data provided by UCSF Profiles, powered by CTSI
    1. Chang Y, Manivannan P, Doosti A, Lapinski PE, Chen D, Roose JP, King PD. Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling. J Immunol. 2023 09 15; 211(6):917-922. View in PubMed
    2. Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Cancer Cell. 2023 05 08; 41(5):853-870.e13. View in PubMed
    3. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports. 2023 03 14; 18(3):636-653. View in PubMed
    4. Hugo Gonzalez, Wenbin Mei, Isabella Robles, Catharina Hagerling, Breanna Allen, Trine Hauge Okholm, Ankitha Nanjaraj, Tamara Verbeek, Sandhya Kalavacherla, Merel van Gogh, Stephen Georgiou, Mariza Daras, Joanna J. Phillips, Matthew H. Spitzer, Jeroen P. Roose, Zena Werb. Abstract IA022: Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment. Cancer Research. 2023 Jan 15; 83(2_Supplement_2):ia022-ia022. View in PubMed
    5. Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. bioRxiv. 2022 Aug 02. View in PubMed
    6. View All Publications

     

     
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